The inappropriate retention of neutrophils at inflammatory sites is a major driver of the
excessive tissue damage characteristic of respiratory inflammatory diseases including COPD, …

Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at
the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal …

10.7554/eLife.50990.001 Neutrophilic inflammation with prolonged neutrophil survival is
common to many inflammatory conditions, including chronic obstructive pulmonary disease (…

Dysregulated neutrophilic inflammation can be highly destructive in chronic inflammatory
diseases due to prolonged neutrophil lifespan and continual release of histotoxic mediators in …

DNA polymerase η (pol η), of the Y‐family, is well known for its in vitro DNA lesion bypass
ability. The most well‐characterized lesion bypassed by this polymerase is the cyclobutane …

Abstract 3173 Background: We evaluated the utility of screening for VTE using a previously
developed clinical risk score (Khorana et al, Blood 2008) in a prospective cohort of cancer …

Elevated levels of reactive oxygen species (ROS) can be induced by exposure to various
chemicals and radiation. One type of damage in DNA produced by ROS is modification of …

The authors performed an angiographic study in six healthy anaesthetized pigs to investigate
possible mechanical effects of contrast injection on coronary artery pressure and diameter …

Despite substantial improvements in the efficacy of therapeutics used to treat chronic
inflammatory diseases over the last several decades, there is a significant unmet need for the …

DNA damage occurs constantly throughout the cell cycle, and can occur intrinsically from
DNA synthesis errors and as a side effect of oxidative respiration or extrinsically from DNA …