S-Acylation is a major post-translational modification affecting several cellular processes. It
is particularly important for neuronal functions. This modification is catalyzed by a family of …

S-acylation, the attachment of fatty acids onto cysteine residues, regulates protein trafficking
and function and is mediated by a family of zDHHC enzymes. The S-acylation of peripheral …

Recently, mutations in the DNAJC5 gene encoding cysteine-string protein α (CSPα) were
identified to cause the neurodegenerative disorder adult-onset neuronal ceroid lipofuscinosis. …

Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently
22 known FA genes. The products of these genes, along with other FA‐associated proteins, …

The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major
breakthroughs in the S-acylation field. Now, more than a decade since their discovery, …

S-acylation is a reversible lipid modification occurring on cysteine residues mediated by a
family of membrane-bound ‘zDHHC’ enzymes. S-acylation predominantly results in anchoring …

Di‐monoubiquitination of the FANCI‐FANCD2 (ID2) complex is a central and crucial step for
the repair of DNA interstrand crosslinks via the Fanconi anaemia pathway. While FANCD2 …

The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand
crosslinks and is additionally activated in response to other forms of replication stress. A key …

S-acylation is an essential post-translational modification, which is mediated by a family of
23 zDHHC enzymes in humans. Several thousand proteins are modified by S-acylation; …

zDHHC S-acyltransferases are enzymes catalyzing protein S-acylation, a common post-translational
modification on proteins frequently affecting their membrane targeting and trafficking…