Transcription and pre-mRNA splicing are key steps in the control of gene expression and
mutations in genes regulating each of these processes are common in leukaemia 1 , 2 . …

How chromatin remodelers cooperate to organize nucleosomes around the start and end of
genes is not known. We determined the genome-wide binding of remodeler complexes SWI/…

Nucleosomal organization in and around genes may contribute substantially to transcriptional
regulation. The contribution of histone modifications to genome-wide nucleosomal …

Metazoan development involves the successive activation and silencing of specific gene
expression programs and is driven by tissue-specific transcription factors programming the …

Recent reports have shown that somatic cells, under appropriate culture conditions, could
be directly reprogrammed to cardiac, hepatic, or neuronal phenotype by lineage-specific …

Somatic mutations commonly occur in hematopoietic stem cells (HSCs). Some mutant
clones outgrow through clonal hematopoiesis (CH) and produce mutated immune progenies …

Methylation of the arginine residues of histones by methyltransferases has important
consequences for chromatin structure and gene regulation; however, the molecular mechanism(s) …

Pluripotent stem cells represent a promising source of differentiated tissue-specific stem and
multipotent progenitor cells for regenerative medicine and drug testing. The realisation of …

Human transcriptional coactivator PC4 is a highly abundant multifunctional protein which
plays diverse important roles in cellular processes, including transcription, replication, and …

Aging causes chronic low-grade inflammation known as inflamm-aging. It is a risk factor for
several chronic disorders, including chronic myelomonocytic leukemia (CMML), a …