Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

Background Large, rare chromosomal deletions and duplications known as copy number
variants (CNVs) have been implicated in neurodevelopmental disorders similar to attention-…

We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases
of schizophrenia and 2792 controls that had been genotyped using the Affymetrix GeneChip® …

Purpose: Neurofibromatosis type 1 (NF1) is an autosomal dominant condition that predisposes
to benign and malignant tumors. The lifetime risk of a malignant peripheral nerve sheath …

Microarray-based comparative genomic hybridization (array-CGH) has emerged as a
revolutionary platform, enabling the high-resolution detection of DNA copy number aberrations. In …

The antipsychotic clozapine is uniquely effective in the management of schizophrenia; however,
its use is limited by its potential to induce agranulocytosis. The causes of this, and of its …

Background Parkinson's disease has been reported in a small number of patients with
chromosome 22q11.2 deletion syndrome. In this study, we screened a series of large, …

Background Meningiomas are the most common intracranial neoplasias, representing a
clinically and histopathologically heterogeneous group of tumors. The neurofibromatosis type 2 (…

We have constructed the first comprehensive microarray representing a human chromosome
for analysis of DNA copy number variation. This chromosome 22 array covers 34.7 Mb, …

Optimal scale selection for image segmentation is an essential component of the Object-Based
Image Analysis (OBIA) and interpretation. An optimal segmentation scale is a scale at …