User profiles for Kirill Grigorev

Kirill Grigorev

Staff Scientist, Blue Marble Space Institute of Science
Verified email at bmsis.org
Cited by 613

Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia

…, RM Brand, S Kothen-Hill, RC Schulman, K Grigorev… - Nature, 2019 - nature.com
Genetic and epigenetic intra-tumoral heterogeneity cooperate to shape the evolutionary
course of cancer 1 . Chronic lymphocytic leukaemia (CLL) is a highly informative model for …

[HTML][HTML] Single-molecule sequencing detection of N6-methyladenine in microbial reference materials

ABR McIntyre, N Alexander, K Grigorev… - Nature …, 2019 - nature.com
The DNA base modification N6-methyladenine (m 6 A) is involved in many pathways related
to the survival of bacteria and their interactions with hosts. Nanopore sequencing offers a …

NASA GeneLab: interfaces for the exploration of space omics data

DC Berrios, J Galazka, K Grigorev… - Nucleic Acids …, 2021 - academic.oup.com
The mission of NASA’s GeneLab database ( https://genelab.nasa.gov/ ) is to collect, curate,
and provide access to the genomic, transcriptomic, proteomic and metabolomic (so-called ‘…

[PDF][PDF] Temporal telomere and DNA damage responses in the space radiation environment

…, MJ Mackay, D Butler, J Foox, K Grigorev… - Cell Reports, 2020 - cell.com
Telomeres, repetitive terminal features of chromosomes essential for maintaining genome
integrity, shorten with cell division, lifestyle factors and stresses, and environmental exposures…

[PDF][PDF] Cell-free DNA (cfDNA) and exosome profiling from a year-long human spaceflight reveals circulating biomarkers

D Bezdan, K Grigorev, C Meydan, FAP Vatter, M Cioffi… - Iscience, 2020 - cell.com
Liquid biopsies based on cell-free DNA (cfDNA) or exosomes provide a noninvasive approach
to monitor human health and disease but have not been utilized for astronauts. Here, we …

Haplotype diversity and sequence heterogeneity of human telomeres

K Grigorev, J Foox, D Bezdan, D Butler… - Genome …, 2021 - genome.cshlp.org
Telomeres are regions of repetitive nucleotide sequences capping the ends of eukaryotic
chromosomes that protect against deterioration, and whose lengths can be correlated with age …

[PDF][PDF] Advancing the integration of biosciences data sharing to further enable space exploration

RT Scott, K Grigorev, G Mackintosh, SG Gebre… - Cell Reports, 2020 - cell.com
Understanding the impact of space exploration remains biologically elusive. Cell Press is
dedicating this month to spaceflight (Afshinnekoo et al., 2020), with the open science NASA …

Mitogenomic sequences support a north–south subspecies subdivision within Solenodon paradoxus

AL Brandt, K Grigorev… - … DNA Part A, 2017 - Taylor & Francis
Solenodons are insectivores found only in Hispaniola and Cuba, with a Mesozoic divergence
date versus extant mainland mammals. Solenodons are the oldest lineage of living …

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during Short duration Spaceflight

…, SA Narayanan, EG Overbey, K Grigorev… - Precision Clinical …, 2024 - academic.oup.com
The Inspiration4 (I4) mission, the first all-civilian orbital flight mission, investigated the
physiological effects of short-duration spaceflight through a multi-omic approach. To provide a …

Innovative assembly strategy contributes to understanding the evolution and conservation genetics of the endangered Solenodon paradoxus from the island of …

K Grigorev, S Kliver, P Dobrynin, A Komissarov… - …, 2018 - academic.oup.com
Solenodons are insectivores that live in Hispaniola and Cuba. They form an isolated branch
in the tree of placental mammals that are highly divergent from other eulipothyplan …