The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …

Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …

Background: Severe anemia is a major cause of sickness and death in African children, yet
the causes of anemia in this population have been inadequately studied. Methods: We …

We report a genome-wide association (GWA) study of severe malaria in The Gambia. The
initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a …

Inducible synthesis of nitric oxide (NO) by macrophages is an important mechanism of the
host defense against intracellular infection in mice, but the evidence for significant levels of …

Increased production of reactive oxygen species and loss of endothelial NO bioactivity are
key features of vascular disease states such as diabetes mellitus. Tetrahydrobiopterin (BH4) …

There is growing epidemiological and molecular evidence that ABO blood group affects host
susceptibility to severe Plasmodium falciparum infection. The high frequency of common …

The widespread distribution and relapsing nature of Plasmodium vivax infection present
major challenges for the elimination of malaria. To characterize the genetic diversity of this …

In vivo characterization of regulatory polymorphisms is a key requirement for next-generation
human genetic analysis. Here we describe haploChIP, a method that uses chromatin …