The non-essential amino acids serine and glycine are used in multiple anabolic processes
that support cancer cell growth and proliferation (reviewed in ref. 1 ). While some cancer cells …

With the emerging role of NF-κB in cancer it is important that its responses to stimuli relevant
to tumor progression and therapy are understood. Here, we demonstrate that NF-κB …

The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic
members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 …

The BH3-mimetic ABT-737 and an orally bioavailable compound of the same class, navitoclax
(ABT-263), have shown promising antitumor efficacy in preclinical and early clinical …

One mechanism by which a cell affords protection from the transforming effects of oncogenes
is via the action of the tumor suppressor, ARF, which activates p53 by inactivating Mdm2. …

Abstract Analysis of publicly available genomic and gene expression data demonstrates that
MCL1 expression is frequently elevated in breast cancer. Distinct from other pro-survival Bcl…

In the 20 years since its discovery, research into the NF-κB (nuclear factor-κB) family of
transcription factors has revealed an amazing diversity of functions. NF-κB proteins are regulators …

The ARF tumour suppressor is a central component of the cellular defence against oncogene
activation. In addition to activating p53 through binding Mdm2, ARF possesses other …

During immune responses, neutrophils must integrate survival and death signals from multiple
sources to regulate their lifespan. Signals that activate either the Bcl-2- or death receptor-…

Diverse human cancers with poor prognosis, including many lymphoid and myeloid
malignancies, exhibit high levels of Mcl-1. To explore the impact of Mcl-1 overexpression on the …