Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish
…, PJ French, E Bindels, KJ Gussinklo… - Blood …, 2021 - ashpublications.org
The differentiation of hematopoietic stem cells (HSCs) is tightly controlled to ensure a proper
balance between myeloid and lymphoid cell output. GATA2 is a pivotal hematopoietic …
balance between myeloid and lymphoid cell output. GATA2 is a pivotal hematopoietic …
Archived bone marrow smears are an excellent source for NGS-based mutation detection in acute myeloid leukemia
…, CAJ Erpelinck-Verschueren, KJ Gussinklo… - Leukemia, 2020 - nature.com
Acute myeloid leukemia (AML) is a heterogeneous disease as illustrated by the enormous
diversity in numbers, types and often patient-specific molecular alterations. The current AML …
diversity in numbers, types and often patient-specific molecular alterations. The current AML …
Single cell transcriptome analysis reveals an essential role for Gata2b in hematopoietic lineage decisions in zebrafish
…, PJ French, E Bindels, R Monteiro, KJ Gussinklo… - Biorxiv, 2019 - biorxiv.org
Hematopoietic stem cells (HSCs) are tightly controlled to keep a balance between myeloid
and lymphoid cell differentiation. Gata2 is a pivotal hematopoietic transcription factor required …
and lymphoid cell differentiation. Gata2 is a pivotal hematopoietic transcription factor required …
[HTML][HTML] High-throughput proteomics identifies THEMIS2 as independent biomarker of treatment-free survival in untreated CLL
…, L van der Straten, HJ Boiten, KJ Gussinklo… - …, 2023 - journals.lww.com
It remains challenging in chronic lymphocytic leukemia (CLL) to distinguish between patients
with favorable and unfavorable time-to-first treatment (TTFT). Additionally, the downstream …
with favorable and unfavorable time-to-first treatment (TTFT). Additionally, the downstream …
High-Throughput Proteomics Identifies THEMIS2 As Biomarker of Inferior Treatment-Free Survival in Chronic Lymphocytic Leukemia
…, L Van Der Straten, HJ Boiten, KJ Gussinklo… - Blood, 2022 - ashpublications.org
Background Notwithstanding advances in the prognostication of chronic lymphocytic
leukemia (CLL), it remains challenging to distinguish between patients with favorable and …
leukemia (CLL), it remains challenging to distinguish between patients with favorable and …
[HTML][HTML] Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis
…, R Rispoli, J Peulen-Zink, K Gussinklo… - Communications …, 2020 - nature.com
Gata2 is a key transcription factor required to generate Haematopoietic Stem and Progenitor
Cells (HSPCs) from haemogenic endothelium (HE); misexpression of Gata2 leads to …
Cells (HSPCs) from haemogenic endothelium (HE); misexpression of Gata2 leads to …
Compensatory mechanisms upon Gata2b haploinsufficiency causes aberrant transcriptional regulatory signatures in HSPCs resulting in myeloid and erythroid …
…, C Koyunlar, J Zink, H de Looper, KJ Gussinklo… - bioRxiv, 2021 - biorxiv.org
The transcription factor GATA2 has pivotal roles in hematopoiesis. Germline GATA2
mutations in patients result in GATA2 haploinsufficiency syndrome characterized by …
mutations in patients result in GATA2 haploinsufficiency syndrome characterized by …
S160: GATA2B HAPLOINSUFFICIENCY CAUSES ABERRANT TRANSCRIPTIONAL REGULATORY SIGNATURES IN HSPCS RESULTING IN MYELOID AND …
…, C Koyunlar, J Zink, H De Looper, KJ Gussinklo… - …, 2023 - journals.lww.com
Background: The transcription factor GATA2 has pivotal roles in hematopoiesis. Germline
GATA2 mutations in patients result in GATA2 haploinsufficiency syndrome characterized by …
GATA2 mutations in patients result in GATA2 haploinsufficiency syndrome characterized by …
[PDF][PDF] Gata2b haploinsufficiency causes aberrant transcriptional signatures in HSPCs resulting in myeloid and erythroid dysplasia in zebrafish
…, C Koyunlar, J Zink, H de Looper, KJ Gussinklo… - academia.edu
The transcription factor GATA2 has pivotal roles in hematopoiesis. Germline GATA2 mutations
result in GATA2 haploinsufficiency characterized by immunodeficiency, bone marrow …
result in GATA2 haploinsufficiency characterized by immunodeficiency, bone marrow …
[PDF][PDF] A zebrafish model for MonoMAC syndrome identifies an earlier role for gata2 in haemogenic endothelium programming and generation of haematopoietic stem …
…, C Koyunlar, R Rispoli, J Peulen-Zink, K Gussinklo… - bioRxiv, 2019 - researchgate.net
Haematopoietic stem and progenitor cells (HSPCs) maintain the vertebrate blood system
throughout life and their emergence from haemogenic endothelium (HE) is tightly regulated by …
throughout life and their emergence from haemogenic endothelium (HE) is tightly regulated by …