Naive pluripotent embryonic stem cells (ESCs) and embryonic germ cells (EGCs) are
derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively. We …

Resistant tumours are thought to arise from the action of Darwinian selection on genetically
heterogenous cancer cell populations. However, simple clonal selection is inadequate to …

Background The field of epigenetics is developing rapidly, however we are only beginning
to comprehend the complexity of its influence on gene regulation. Using genomic imprinting …

Cultured pluripotent stem cells hold great promise for regenerative medicine. Considerable
efforts have been invested into the refinement and definition of improved culture systems that …

Gene expression is controlled by networks of transcription factors and regulators, but the
structure of these networks is as yet poorly understood and is thus inferred from data. Recent …

Genomic imprinting is a normal process found in plants and mammals. Imprinted genes are
characterised by expression that is dependent on the parental-origin of the gene such that …

Pluripotent stem cells (PSCs) can self-renew indefinitely while maintaining the ability to
generate all cell types of the body. This plasticity is proposed to require heterogeneity in gene …

The recent discovery of Tet (Ten eleven translocation) family of enzymes implicated in the
chemical conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-…

Now a popular and widely used term,“Epigenetics” has changed its meaning several times
since “epigenesis” was debated by Greek philosophers as an alternative to existence of the …