c-FLIP is an inhibitor of apoptosis mediated by the death receptors Fas, DR4, and DR5 and
is expressed as long (c-FLIP L ) and short (c-FLIP S ) splice forms. We found that small …

Colloidal nanoparticle drug delivery systems have attracted much interest for their ability to
enable effective formulation and delivery of therapeutic agents. The selective delivery of …

meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate (TMP) is a photosensitizer that can
be used in photodynamic therapy (PDT) to induce cell death through generation of reactive …

INTRODUCTION: Malignant pleural mesothelioma (MPM) is a rapidly fatal malignancy that
is increasing in incidence. The caspase 8 inhibitor FLIP is an anti-apoptotic protein over-…

p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the molecular
basis of the switch from p53-induced cell-cycle arrest to apoptosis remains poorly understood. …

How p53 differentially activates cell cycle arrest versus cell death remains poorly understood.
Here, we demonstrate that upregulation of canonical pro-apoptotic p53 target genes in …

Background: How p53 differentially activates cell cycle arrest versus cell death remains poorly
understood. Understanding the mechanisms governing the switch from p53-induced cell-…

Background Concomitant administration of COVID-19 and influenza vaccines could reduce
burden on health-care systems. We aimed to assess the safety of concomitant administration …

The reasons why animal populations decline in response to anthropogenic noise are still
poorly understood. To understand how populations are affected by noise, we must understand …

Anthropogenic noise can affect behaviour across a wide range of species in both terrestrial
and aquatic environments. However, behaviours might not be affected in isolation. Therefore, …