User profiles for Klaas W. Mulder
 | Klaas W. MulderAssociate Professor, Molecular Developmental Biology, Radboud University Verified email at science.ru.nl Cited by 3212 |
[HTML][HTML] Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4
M Vermeulen, KW Mulder, S Denissov… - Cell, 2007 - cell.com
Trimethylation of histone H3 at lysine 4 (H3K4me3) is regarded as a hallmark of active
human promoters, but it remains unclear how this posttranslational modification links to …
human promoters, but it remains unclear how this posttranslational modification links to …
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
The dermal papilla comprises the specialised mesenchymal cells at the base of the hair
follicle. Communication between dermal papilla cells and the overlying epithelium is essential …
follicle. Communication between dermal papilla cells and the overlying epithelium is essential …
Menin links estrogen receptor activation to histone H3K4 trimethylation
KMA Dreijerink, KW Mulder, GS Winkler… - Cancer research, 2006 - AACR
The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene, menin,
is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for …
is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for …
Human Ccr4–Not complexes contain variable deadenylase subunits
The Ccr4–Not complex is evolutionarily conserved and important for regulation of mRNA
synthesis and decay. The composition of the yeast complex has been well described. …
synthesis and decay. The composition of the yeast complex has been well described. …
Diverse epigenetic strategies interact to control epidermal differentiation
It is becoming clear that interconnected functional gene networks, rather than individual
genes, govern stem cell self-renewal and differentiation. To identify epigenetic factors that …
genes, govern stem cell self-renewal and differentiation. To identify epigenetic factors that …
Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties
…, M Kayikci, R Russell, K Kretzschmar, KW Mulder… - Nature cell …, 2017 - nature.com
The epidermis is maintained by multiple stem cell populations whose progeny differentiate
along diverse, and spatially distinct, lineages. Here we show that the transcription factor …
along diverse, and spatially distinct, lineages. Here we show that the transcription factor …
Human Ccr4‐Not complex is a ligand‐dependent repressor of nuclear receptor‐mediated transcription
GS Winkler, KW Mulder, VJ Bardwell… - The EMBO …, 2006 - embopress.org
The Ccr4‐Not complex is a highly conserved regulator of mRNA metabolism. The transcription
regulatory function of this complex in higher eukaryotes, however, is largely unexplored. …
regulatory function of this complex in higher eukaryotes, however, is largely unexplored. …
[HTML][HTML] Combined quantification of intracellular (phospho-) proteins and transcriptomics from fixed single cells
Environmental stimuli often lead to heterogeneous cellular responses and transcriptional
output. We developed single-cell RNA and Immunodetection (RAID) to allow combined …
output. We developed single-cell RNA and Immunodetection (RAID) to allow combined …
[HTML][HTML] A covalent and cleavable antibody-DNA conjugation strategy for sensitive protein detection via immuno-PCR
Immuno-PCR combines specific antibody-based protein detection with the sensitivity of PCR-based
quantification through the use of antibody-DNA conjugates. The production of such …
quantification through the use of antibody-DNA conjugates. The production of such …
Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism
Mutations in the daf‐2 gene of the conserved Insulin/Insulin‐like Growth Factor (IGF‐1)
pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is …
pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is …