Mitochondria dysfunction is involved in the pathomechanism of many illnesses including
Parkinson’s disease. PINK1, which is mutated in some cases of familial Parkinsonism, is a key …

Mitochondria are organelles indispensable for the correct functioning of eukaryotic cells.
Their significance for cellular homeostasis is manifested by the existence of complex quality …

PINK1 loss-of-function mutations cause early onset Parkinson disease. PINK1-Parkin mediated
mitophagy has been well studied, but the relevance of the endogenous process in the …

Polymerase δ‐interacting protein 2 (POLDIP2, PDIP38) is a multifaceted, “moonlighting”
protein, involved in binding protein partners from many different cellular processes, including …

Mitochondria dysfunction is involved in the pathomechanism of many illnesses including
Parkinson’s disease. PINK1, which is mutated in some cases of familiar Parkinsonism, is a key …

Mitochondrial dysfunction contributes to the pathogenesis of Parkinson’s disease but it is
not clear why inherent mitochondrial defects lead specifically to the death of dopaminergic …

To the Editor: We read with great interest the recent report by Bonifati et al. demonstrating that
the transcript of an allele bearing the c. 1366CT (Gln456Stop) mutation in the PINK1 gene …

Background PINK1 is a mitochondria-targeted kinase that constitutively localizes to both the
mitochondria and the cytosol. The mechanism of how PINK1 achieves cytosolic localization …

Polymerase δ-interacting Protein 2 (POLDIP2) is composed of 368 amino acids, with a
molecular weight of the 42 kDa and 37 kDa, respectively, before and after post-translational …

Mitochondrial outer membrane β‐barrel proteins are encoded in the nucleus, translated in
the cytosol and then targeted to and imported into the respective organelles. Detailed studies …