The precise spatio-temporal dynamics of protein activity are often critical in determining cell
behaviour, yet for most proteins they remain poorly understood; it remains difficult to …

The GTPases Rac1, RhoA and Cdc42 act together to control cytoskeleton dynamics 1 , 2 , 3
. Recent biosensor studies have shown that all three GTPases are activated at the front of …

Rho family GTPases regulate the actin and adhesion dynamics that control cell migration.
Current models postulate that Rac promotes membrane protrusion at the leading edge and …

Signaling proteins are thought to be tightly regulated spatially and temporally in order to
generate specific and localized effects. For Rac and other small guanosine triphosphatases, …

Macropinocytosis is differentiated from other types of endocytosis by its unique susceptibility
to inhibitors of Na + /H + exchange. Yet, the functional relationship between Na + /H + …

Dendritic spines are the major loci of synaptic plasticity and are considered as possible
structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of …

OBJECTIVE: Previous work suggests that patients with unipolar depression may have
structural as well as functional abnormalities in limbic-thalamic-cortical networks, which are …

EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes
methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a …

Signaling proteins are tightly regulated spatially and temporally to perform multiple functions.
For Cdc42 and other guanosine triphosphatases, the subcellular location of activation is a …

Cell polarity is crucial for directed migration. Here we show that phosphoinositide 3-kinase (PI(3)K)
mediates neutrophil migration in vivo by differentially regulating cell protrusion and …