Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require
adhesion and transmigration through blood-vessel walls. The traditional three steps of rolling, …

Atherosclerosis is an inflammatory disease of the wall of large- and medium-sized arteries
that is precipitated by elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. …

Rationale: It is assumed that atherosclerotic arteries contain several macrophage subsets
endowed with specific functions. The precise identity of these subsets is poorly characterized …

Monocytes and macrophages are critical effectors and regulators of inflammation and the
innate immune response, the immediate arm of the immune system. Dendritic cells initiate and …

Chemokines regulate inflammation, leukocyte trafficking, and immune cell differentiation.
The role of chemokines in homing of naive T lymphocytes to secondary lymphatic organs is …

Oestrogen produces diverse biological effects through binding to the oestrogen receptor (ER)
1 . The ER is a steroid hormone nuclear receptor, which, when bound to oestrogen, …

Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue macrophages
are seeded in the early embryo before definitive hematopoiesis is established. Others …

The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that
have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. …

We studied whether circulating activated platelets and platelet–leukocyte aggregates cause
the development of atherosclerotic lesions in apolipoprotein-E–deficient (Apoe −/− ) mice. …

There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic
inflammatory disease. Lessons from genome-wide association studies, advanced in vivo …