Importance High-dose immunosuppressive therapy and autologous hematopoietic stem cell
transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small …

The heterogeneity of common variable immunodeficiency (CVID) calls for a classification
addressing pathogenic mechanisms as well as clinical relevance. This European multicenter …

No genetic defect is known to cause common variable immunodeficiency (CVID), a heterogeneous
human disorder leading to adult-onset panhypogammaglobulinemia. In a search for …

Background Chronic mucocutaneous candidiasis may be manifested as a primary
immunodeficiency characterized by persistent or recurrent infections of the mucosa or the skin with …

The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of
immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family …

The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …

Hypogammaglobulinemia is the hallmark of common variable immunodeficiency (CVID)
syndrome, a heterogeneous disorder predisposing patients to recurrent bacterial infections. In …

To update the European League Against Rheumatism (EULAR) recommendations for vaccination
in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) published …

Background Common variable immunodeficiency (CVID) is an antibody deficiency with an
equal sex distribution and a high variability in clinical presentation. The main features include …

ICOS is expressed on activated T cells and particularly on CXCR5+ follicular Th cells in germinal
centers (GC). Its deletion leads to a profound deficiency in memory B cell formation and …