Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated
in anxiety in humans and animal models and is the site of action of widely used uptake-…

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

The gene encoding the serotonin transporter (5-HTT) contains a regulatory variation that
has been associated with anxiety-related traits and susceptibility for depression. Here we …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

A genetic contribution to the pathogenesis of panic disorder has been demonstrated by clinical
genetic studies. Molecular genetic studies have focused on candidate genes suggested …

A cDNA encoding the human platelet serotonin (5‐HT) uptake site was isolated and sequenced
using the PCR. The cDNA represents a 3.1‐kb mRNA transcript and contains an open …

Background Neuroimaging studies have shown structural alterations in several brain regions
in children and adults with attention deficit hyperactivity disorder (ADHD). Through the …

The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT)
provides the primary mechanism for inactivation of 5-HT after its release into the synaptic …

OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity
disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide …

The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …