Accurate modeling of the molecular subtypes of pancreatic cancer is crucial to facilitate the
generation of effective therapies. We report the development of an intraductal organoid …

The aberrant expression of squamous lineage markers in pancreatic ductal adenocarcinoma
(PDA) has been correlated with poor clinical outcomes. However, the functional role of this …

Objective It has been discussed whether IgG4-related disease (IgG4-RD), including
autoimmune pancreatitis (AIP), is associated with malignancy; however, the issue has not been …

Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized
by an expanded stroma with marked fibrosis (desmoplasia). We previously generated …

Objective Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated
thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor …

Background Wire-guided cannulation (WGC) was reported to decrease post-ERCP pancreatitis
(PEP), but risk factors for PEP in WGC are not fully elucidated. Objective To evaluate the …

The hedgehog and mitogen‐activated protein kinase (MAPK) signaling pathways regulate
growth in many tumors, suggesting cooperation between these two pathways in the …

Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We …

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies,
owing in part to its propensity for metastasis. Here, we used an organoid culture system to …

Background Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic
masses is an established procedure for obtaining a pathological specimen. However, …