VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
…, L Vincent, C Costa, DD MacDonald, DK Jin, K Shido… - Nature, 2005 - nature.com
The cellular and molecular mechanisms by which a tumour cell undergoes metastasis to a
predetermined location are largely unknown. Here we demonstrate that bone marrow-derived …
predetermined location are largely unknown. Here we demonstrate that bone marrow-derived …
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
The molecular pathways involved in the differentiation of hematopoietic progenitors are
unknown. Here we report that chemokine-mediated interactions of megakaryocyte progenitors …
unknown. Here we report that chemokine-mediated interactions of megakaryocyte progenitors …
Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
…, Z Rosenwaks, V Mittal, H Kobayashi, K Shido… - Nature, 2010 - nature.com
During embryogenesis, endothelial cells induce organogenesis before the development of
circulation 1 , 2 , 3 , 4 . These findings suggest that endothelial cells not only form passive …
circulation 1 , 2 , 3 , 4 . These findings suggest that endothelial cells not only form passive …
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes
DK Jin, K Shido, HG Kopp, I Petit, SV Shmelkov… - Nature medicine, 2006 - nature.com
The mechanisms through which hematopoietic cytokines accelerate revascularization are
unknown. Here, we show that the magnitude of cytokine-mediated release of SDF-1 from …
unknown. Here, we show that the magnitude of cytokine-mediated release of SDF-1 from …
[PDF][PDF] Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
…, H Kobayashi, AT Hooper, M Seandel, K Shido… - Cell stem cell, 2010 - cell.com
Bone marrow endothelial cells (ECs) are essential for reconstitution of hematopoiesis, but
their role in self-renewal of long-term hematopoietic stem cells (LT-HSCs) is unknown. We …
their role in self-renewal of long-term hematopoietic stem cells (LT-HSCs) is unknown. We …
[PDF][PDF] Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells
…, A Kranz, K Iida, M Kobayashi, HG Kopp, K Shido… - Cell stem cell, 2009 - cell.com
Myelosuppression damages the bone marrow (BM) vascular niche, but it is unclear how
regeneration of bone marrow vessels contributes to engraftment of transplanted hematopoietic …
regeneration of bone marrow vessels contributes to engraftment of transplanted hematopoietic …
[PDF][PDF] Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration
Microvascular endothelial cells (ECs) within different tissues are endowed with distinct but
as yet unrecognized structural, phenotypic, and functional attributes. We devised EC …
as yet unrecognized structural, phenotypic, and functional attributes. We devised EC …
Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis
Chemical or traumatic damage to the liver is frequently associated with aberrant healing (fibrosis)
that overrides liver regeneration 1 , 2 , 3 , 4 , 5 . The mechanism by which hepatic …
that overrides liver regeneration 1 , 2 , 3 , 4 , 5 . The mechanism by which hepatic …
[HTML][HTML] Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization
…, RG Crystal, M Simons, TN Sato, S Worgall, K Shido… - Cell, 2011 - cell.com
To identify pathways involved in adult lung regeneration, we employ a unilateral pneumonectomy
(PNX) model that promotes regenerative alveolarization in the remaining intact lung. …
(PNX) model that promotes regenerative alveolarization in the remaining intact lung. …
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
Endothelial cells establish an instructive vascular niche that reconstitutes haematopoietic stem
and progenitor cells (HSPCs) through release of specific paracrine growth factors, known …
and progenitor cells (HSPCs) through release of specific paracrine growth factors, known …