VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

…, L Vincent, C Costa, DD MacDonald, DK Jin, K Shido… - Nature, 2005 - nature.com
The cellular and molecular mechanisms by which a tumour cell undergoes metastasis to a
predetermined location are largely unknown. Here we demonstrate that bone marrow-derived …

Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

…, K Hattori, B Heissig, R Tejada, F Liao, K Shido… - Nature medicine, 2004 - nature.com
The molecular pathways involved in the differentiation of hematopoietic progenitors are
unknown. Here we report that chemokine-mediated interactions of megakaryocyte progenitors …

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

…, Z Rosenwaks, V Mittal, H Kobayashi, K Shido… - Nature, 2010 - nature.com
During embryogenesis, endothelial cells induce organogenesis before the development of
circulation 1 , 2 , 3 , 4 . These findings suggest that endothelial cells not only form passive …

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

DK Jin, K Shido, HG Kopp, I Petit, SV Shmelkov… - Nature medicine, 2006 - nature.com
The mechanisms through which hematopoietic cytokines accelerate revascularization are
unknown. Here, we show that the magnitude of cytokine-mediated release of SDF-1 from …

[PDF][PDF] Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells

…, H Kobayashi, AT Hooper, M Seandel, K Shido… - Cell stem cell, 2010 - cell.com
Bone marrow endothelial cells (ECs) are essential for reconstitution of hematopoiesis, but
their role in self-renewal of long-term hematopoietic stem cells (LT-HSCs) is unknown. We …

[PDF][PDF] Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells

…, A Kranz, K Iida, M Kobayashi, HG Kopp, K Shido… - Cell stem cell, 2009 - cell.com
Myelosuppression damages the bone marrow (BM) vascular niche, but it is unclear how
regeneration of bone marrow vessels contributes to engraftment of transplanted hematopoietic …

[PDF][PDF] Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration

…, Z Rosenwaks, JM Butler, J Xiang, A Rafii, K Shido… - Developmental cell, 2013 - cell.com
Microvascular endothelial cells (ECs) within different tissues are endowed with distinct but
as yet unrecognized structural, phenotypic, and functional attributes. We devised EC …

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

…, DJ Nolan, P Guo, M Simons, ME Penfold, K Shido… - Nature, 2014 - nature.com
Chemical or traumatic damage to the liver is frequently associated with aberrant healing (fibrosis)
that overrides liver regeneration 1 , 2 , 3 , 4 , 5 . The mechanism by which hepatic …

[HTML][HTML] Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization

…, RG Crystal, M Simons, TN Sato, S Worgall, K Shido… - Cell, 2011 - cell.com
To identify pathways involved in adult lung regeneration, we employ a unilateral pneumonectomy
(PNX) model that promotes regenerative alveolarization in the remaining intact lung. …

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

…, BS Ding, B Bonner, VK Chiu, DJ Nolan, K Shido… - Nature cell …, 2010 - nature.com
Endothelial cells establish an instructive vascular niche that reconstitutes haematopoietic stem
and progenitor cells (HSPCs) through release of specific paracrine growth factors, known …