Many models of morphogenesis are forced to assume specific mechanical properties of cells,
because the actual mechanical properties of living tissues are largely unknown. Here, we …

We present an oblique plane microscope (OPM) that uses a bespoke glass-tipped tertiary
objective to improve the resolution, field of view, and usability over previous variants. Owing to …

Epithelial folding mediated by apical constriction converts flat epithelial sheets into multilayered,
complex tissue structures and is used throughout development in most animals 1 . Little …

Across metazoans, animal body structures and tissues exist in robust patterns that arise
seemingly out of stochasticity of a few early cells in the embryo. These patterns ensure proper …

Wnt ligands are considered classical morphogens, for which the strength of the cellular
response is proportional to the concentration of the ligand. Herein, we show an emergent …

Understanding tissue morphogenesis is impossible without knowing the mechanical properties
of the tissue being shaped. Although techniques for measuring tissue material properties …

In order to understand morphogenesis, it is necessary to know the material properties or
forces shaping the living tissue. In spite of this need, very few in vivo measurements are …

Understanding how forces and material properties give rise to tissue shapes is a fundamental
issue in developmental biology. Although Drosophila gastrulation is a well-used system …

Cell motility is driven primarily by the dynamics of the cell cytoskeleton, a system of
filamentous proteins and molecular motors. It has been proposed that cell motility is a self-organized …

The Bacillus subtilis Spo0J/Soj proteins, implicated in chromosome segregation and
transcriptional regulation, show striking dynamics: Soj undergoes irregular relocations from pole to …