Masculinization of the external genitalia in humans is dependent on formation of 5α-dihydrotestosterone
(DHT) through both the canonical androgenic pathway and an alternative (…

The liver X receptor (LXR)α and -β has been found to play a central role in maintaining
cellular cholesterol homeostasis. In this study we comprehensively investigated the effect of …

Different isoforms of testicular interleukin-1 (IL-1) were analysed to determine whether there
were differences in the ability to modulate rat Leydig cell steroidogenesis in vitro. Rat 17K IL-…

Di-2-ethylhexyl (DEHP) phthalate, one of the phthalates most widely distributed in our general
environment, causes reproductive toxicity that is attributable to the action of its primary …

Aim: We aim to examine the steroidogenic phenotype and the differentiation potential of human
testicular peritubular cells (HTPCs) and to explore their possible relationship to the adult …

Resveratrol and its analogs are considered to be a promising drug candidate for treatment
of cancer and different age‐associated diseases. In the present study we have investigated …

Although three-dimensional testicular cell cultures have been demonstrated to mimic the
organization of the testis in vivo and support spermatogenesis, the optimal culture conditions …

The present investigation examines the influence of IGF-I and the role of IGF-I receptor (IGF-IR)
in the apoptosis/survival of Leydig cells. Immunohistochemical analysis of the rat testis at …

Humanin (HN) is a 24 amino acids peptide with potent neuro‐survival properties that
protects against damage associated with Alzheimer's disease. In the present report, we have …

During the past few decades, scientific evidence has been accumulated concerning the possible
adverse effects of the exposure to environmental chemicals on the well-being of wildlife …