Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying
mechanisms are not understood. Single-cell analyses of patient-derived models and clinical …

Renewable neurosphere formation in culture is a defining characteristic of certain brain
tumor initiating cells. This retrospective study was designed to assess the relationship among …

At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain
tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain …

Glioblastoma (GBM) is among the most lethal of all cancers. GBM consist of a
heterogeneous population of tumor cells among which a tumor-initiating and treatment-resistant …

Peripheral T-cell lymphomas are a heterogeneous group of lymphoid malignancies. Among
these, hepatosplenic γδ T-cell lymphoma (HTCL) represents an aggressive and treatment-…

Glioblastoma multiforme (GBM) is a devastating disease, and the current therapies have only
palliative effect. Evidence is mounting to indicate that brain tumor stem cells (BTSCs) are a …

Background and Purpose— In chronic hydrocephalus, a role for tissue hypoxia resulting
from cerebrovascular compression is suggested. The purpose of this study was to evaluate …

Multipotent neural progenitor cells or neural stem cells (NSC) can be propagated in vitro
from a variety of sources and have great potential for neural repair. Although it is well known …

Neural progenitor transplantation is a potential treatment for neurodegenerative diseases,
including Huntington's disease (HD). In the current study, we tested the potential of rat …

Background Clinical trials of therapies directed against nodes of the signaling axis of
phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin (mTOR) in glioblastoma (GBM) …