Plasticity of innate lymphoid cell subsets

SM Bal, K Golebski, H Spits - Nature Reviews Immunology, 2020 - nature.com
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can be …

Emerging roles of innate lymphoid cells in inflammatory diseases: clinical implications

I Kortekaas Krohn, MM Shikhagaie, K Golebski… - Allergy, 2018 - Wiley Online Library
Innate lymphoid cells ( ILC ) represent a group of lymphocytes that lack specific antigen
receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles …

New insights into the function, development, and plasticity of type 2 innate lymphoid cells

…, SM Bal, H Spits, K Golebski - Immunological …, 2018 - Wiley Online Library
Group 2 innate lymphoid cells ( ILC 2s) are the most well defined group of ILC s. ILC 2
development is controlled by the GATA ‐3 transcription factor and these cells produce archetypal …

[PDF][PDF] The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells

J Mjösberg, J Bernink, K Golebski, JJ Karrich… - immunity, 2012 - cell.com
Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important
effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate …

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

…, TG Caniels, K van der Straten, K Golebski… - Science translational …, 2021 - science.org
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

[PDF][PDF] Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

K Golebski, JA Layhadi, U Sahiner, EH Steveling-Klein… - Immunity, 2021 - cell.com
The role of innate immune cells in allergen immunotherapy that confers immune tolerance to
the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 …

Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases

EK van der Ploeg, K Golebski, M van Nimwegen… - Science …, 2021 - science.org
Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have
been implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s (…

[HTML][HTML] IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation

K Golebski, XR Ros, M Nagasawa, S van Tol… - Nature …, 2019 - nature.com
Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs
coordinate early eradication of pathogens and contribute to tissue healing and remodeling, …

KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2 ILCs biased toward ILC2 or ILC3

…, MJW de Bruijn, K Golebski… - Journal of Experimental …, 2019 - rupress.org
Recently, human ILCs that express CD117 and CD127 but lack CRTH2 and NKp44 have
been shown to contain precursors of ILC1, ILC2, and ILC3. However, these ILCs have not …

Treating severe asthma: targeting the IL‐5 pathway

…, D Kjærsgaard Klein, K Golebski… - Clinical & …, 2021 - Wiley Online Library
Severe asthma is a heterogeneous disease with different phenotypes based on clinical,
functional or inflammatory parameters. In particular, the eosinophilic phenotype is associated …