Plasticity of innate lymphoid cell subsets
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can be …
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can be …
Emerging roles of innate lymphoid cells in inflammatory diseases: clinical implications
I Kortekaas Krohn, MM Shikhagaie, K Golebski… - Allergy, 2018 - Wiley Online Library
Innate lymphoid cells ( ILC ) represent a group of lymphocytes that lack specific antigen
receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles …
receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles …
New insights into the function, development, and plasticity of type 2 innate lymphoid cells
Group 2 innate lymphoid cells ( ILC 2s) are the most well defined group of ILC s. ILC 2
development is controlled by the GATA ‐3 transcription factor and these cells produce archetypal …
development is controlled by the GATA ‐3 transcription factor and these cells produce archetypal …
[PDF][PDF] The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells
Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important
effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate …
effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate …
High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages
…, TG Caniels, K van der Straten, K Golebski… - Science translational …, 2021 - science.org
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …
around the time of activation of the adaptive immune response. Here, we provide evidence …
[PDF][PDF] Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response
K Golebski, JA Layhadi, U Sahiner, EH Steveling-Klein… - Immunity, 2021 - cell.com
The role of innate immune cells in allergen immunotherapy that confers immune tolerance to
the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 …
the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 …
Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases
EK van der Ploeg, K Golebski, M van Nimwegen… - Science …, 2021 - science.org
Group 2 innate lymphoid cells (ILC2s) orchestrate protective type 2 immunity and have
been implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s (…
been implicated in various immune disorders. In the mouse, circulatory inflammatory ILC2s (…
[HTML][HTML] IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation
K Golebski, XR Ros, M Nagasawa, S van Tol… - Nature …, 2019 - nature.com
Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs
coordinate early eradication of pathogens and contribute to tissue healing and remodeling, …
coordinate early eradication of pathogens and contribute to tissue healing and remodeling, …
KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2− ILCs biased toward ILC2 or ILC3
…, MJW de Bruijn, K Golebski… - Journal of Experimental …, 2019 - rupress.org
Recently, human ILCs that express CD117 and CD127 but lack CRTH2 and NKp44 have
been shown to contain precursors of ILC1, ILC2, and ILC3. However, these ILCs have not …
been shown to contain precursors of ILC1, ILC2, and ILC3. However, these ILCs have not …
Treating severe asthma: targeting the IL‐5 pathway
…, D Kjærsgaard Klein, K Golebski… - Clinical & …, 2021 - Wiley Online Library
Severe asthma is a heterogeneous disease with different phenotypes based on clinical,
functional or inflammatory parameters. In particular, the eosinophilic phenotype is associated …
functional or inflammatory parameters. In particular, the eosinophilic phenotype is associated …