User profiles for Kosaku Shinoda

Kosaku Shinoda

Assistant Professor, Albert Einstein College of Medicine
Verified email at einsteinmed.org
Cited by 6592

[HTML][HTML] PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein

H Ohno, K Shinoda, BM Spiegelman, S Kajimura - Cell metabolism, 2012 - cell.com
Brown adipose tissue dissipates energy through heat and functions as a defense against cold
and obesity. PPARγ ligands have been shown to induce the browning of white adipocytes; …

[HTML][HTML] Human BAT possesses molecular signatures that resemble beige/brite cells

LZ Sharp, K Shinoda, H Ohno, DW Scheel, E Tomoda… - PloS one, 2012 - journals.plos.org
Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals
from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes …

[PDF][PDF] Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance

S Altshuler-Keylin, K Shinoda, Y Hasegawa, K Ikeda… - Cell metabolism, 2016 - cell.com
Beige adipocytes gained much attention as an alternative cellular target in anti-obesity
therapy. While recent studies have identified a number of regulatory circuits that promote beige …

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex

H Ohno, K Shinoda, K Ohyama, LZ Sharp, S Kajimura - Nature, 2013 - nature.com
Brown adipose tissue (BAT) dissipates chemical energy in the form of heat as a defence
against hypothermia and obesity. Current evidence indicates that brown adipocytes arise from …

[HTML][HTML] The impact of single-cell genomics on adipose tissue research

A Deutsch, D Feng, JE Pessin, K Shinoda - International Journal of …, 2020 - mdpi.com
Adipose tissue is an important regulator of whole-body metabolism and energy homeostasis.
The unprecedented growth of obesity and metabolic disease worldwide has required …

[PDF][PDF] A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat

…, MP Jedrychowski, BK Erickson, K Shinoda… - Cell, 2015 - cell.com
Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their
thermogenic activities can combat obesity and diabetes. Herein the functional adaptations …

[HTML][HTML] Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications* S

N Sugiyama, T Masuda, K Shinoda, A Nakamura… - Molecular & Cellular …, 2007 - ASBMB
We developed novel methods for phosphopeptide enrichment using aliphatic hydroxy acid-modified
metal oxide chromatography (MOC). Titania and zirconia were successfully applied …

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

…, JP Camporez, H Maki, M Homma, K Shinoda… - Nature medicine, 2017 - nature.com
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown
fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent …

Genetic and functional characterization of clonally derived adult human brown adipocytes

K Shinoda, IHN Luijten, Y Hasegawa, H Hong… - Nature medicine, 2015 - nature.com
Brown adipose tissue (BAT) acts in mammals as a natural defense system against
hypothermia, and its activation to a state of increased energy expenditure is believed to protect …

[PDF][PDF] Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans

…, P Annamalai, C Yfanti, T Chao, D Wong, K Shinoda… - Cell metabolism, 2016 - cell.com
Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose
metabolism in humans. However, the physiological significance of human BAT in lipid …