User profiles for Kosaku Shinoda
Kosaku ShinodaAssistant Professor, Albert Einstein College of Medicine Verified email at einsteinmed.org Cited by 6592 |
[HTML][HTML] PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
Brown adipose tissue dissipates energy through heat and functions as a defense against cold
and obesity. PPARγ ligands have been shown to induce the browning of white adipocytes; …
and obesity. PPARγ ligands have been shown to induce the browning of white adipocytes; …
[HTML][HTML] Human BAT possesses molecular signatures that resemble beige/brite cells
LZ Sharp, K Shinoda, H Ohno, DW Scheel, E Tomoda… - PloS one, 2012 - journals.plos.org
Brown adipose tissue (BAT) dissipates chemical energy and generates heat to protect animals
from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes …
from cold and obesity. Rodents possess two types of UCP-1 positive brown adipocytes …
[PDF][PDF] Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance
S Altshuler-Keylin, K Shinoda, Y Hasegawa, K Ikeda… - Cell metabolism, 2016 - cell.com
Beige adipocytes gained much attention as an alternative cellular target in anti-obesity
therapy. While recent studies have identified a number of regulatory circuits that promote beige …
therapy. While recent studies have identified a number of regulatory circuits that promote beige …
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
Brown adipose tissue (BAT) dissipates chemical energy in the form of heat as a defence
against hypothermia and obesity. Current evidence indicates that brown adipocytes arise from …
against hypothermia and obesity. Current evidence indicates that brown adipocytes arise from …
[HTML][HTML] The impact of single-cell genomics on adipose tissue research
Adipose tissue is an important regulator of whole-body metabolism and energy homeostasis.
The unprecedented growth of obesity and metabolic disease worldwide has required …
The unprecedented growth of obesity and metabolic disease worldwide has required …
[PDF][PDF] A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
…, MP Jedrychowski, BK Erickson, K Shinoda… - Cell, 2015 - cell.com
Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their
thermogenic activities can combat obesity and diabetes. Herein the functional adaptations …
thermogenic activities can combat obesity and diabetes. Herein the functional adaptations …
[HTML][HTML] Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications* S
We developed novel methods for phosphopeptide enrichment using aliphatic hydroxy acid-modified
metal oxide chromatography (MOC). Titania and zirconia were successfully applied …
metal oxide chromatography (MOC). Titania and zirconia were successfully applied …
UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
…, JP Camporez, H Maki, M Homma, K Shinoda… - Nature medicine, 2017 - nature.com
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown
fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent …
fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent …
Genetic and functional characterization of clonally derived adult human brown adipocytes
K Shinoda, IHN Luijten, Y Hasegawa, H Hong… - Nature medicine, 2015 - nature.com
Brown adipose tissue (BAT) acts in mammals as a natural defense system against
hypothermia, and its activation to a state of increased energy expenditure is believed to protect …
hypothermia, and its activation to a state of increased energy expenditure is believed to protect …
[PDF][PDF] Brown adipose tissue activation is linked to distinct systemic effects on lipid metabolism in humans
Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose
metabolism in humans. However, the physiological significance of human BAT in lipid …
metabolism in humans. However, the physiological significance of human BAT in lipid …