Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch

K Fujimaki, R Li, H Chen… - Proceedings of the …, 2019 - National Acad Sciences
The reactivation of quiescent cells to proliferate is fundamental to tissue repair and homeostasis
in the body. Often referred to as the G0 state, quiescence is, however, not a uniform …

Cell dormancy plasticity: quiescence deepens into senescence through a dimmer switch

K Fujimaki, G Yao - Physiological genomics, 2020 - journals.physiology.org
Both being dormant cellular states, quiescence and senescence are traditionally considered
distinct. Quiescence is reversible to proliferation upon growth signals, whereas senescence …

[HTML][HTML] Exit from quiescence displays a memory of cell growth and division

X Wang, K Fujimaki, GC Mitchell, JS Kwon… - Nature …, 2017 - nature.com
Reactivating quiescent cells to proliferate is critical to tissue repair and homoeostasis.
Quiescence exit is highly noisy even for genetically identical cells under the same environmental …

[HTML][HTML] The InsP7 phosphatase Siw14 regulates inositol pyrophosphate levels to control localization of the general stress response transcription factor Msn2

EA Steidle, VA Morrissette, K Fujimaki, L Chong… - Journal of Biological …, 2020 - ASBMB
The environmental stress response (ESR) is critical for cell survival. Yeast cells unable to
synthesize inositol pyrophosphates (PP-InsPs) are unable to induce the ESR. We recently …

Cutting edge: AhR is a molecular target of calcitriol in human T cells

M Takami, K Fujimaki, MI Nishimura… - The Journal of …, 2015 - journals.aai.org
The immunoregulatory functions of vitamin D have been well documented in various
immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a …

[HTML][HTML] Transcriptome dynamics in early embryos of the ascidian, Ciona intestinalis

T Matsuoka, T Ikeda, K Fujimaki, Y Satou - Developmental biology, 2013 - Elsevier
Maternally provided mRNAs and proteins direct early development and activate the zygotic
genome. Using microarrays, we examined the dynamics of transcriptomes during the early …

Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy

K Fujimaki, G Yao - Molecular & cellular oncology, 2018 - Taylor & Francis
The regulation of cellular quiescence underlies numerous physiopathological phenomena.
We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by …

Knockdown of rotund gene through larval RNA interference affects genital and elytral morphology in the ground beetle Carabus maiyasanus (Coleoptera: Carabidae …

…, H Sugawara, T Fujisawa, K Fujimaki… - Entomological …, 2018 - Wiley Online Library
Interspecific variation in genital morphology contributes to prezygotic reproductive isolation
in many insect species. However, developmental genes affecting genital morphology are …

Comparative transcriptomic analysis of two closely related ground beetle species with marked genital divergence using pyrosequencing

K Fujimaki, T Fujisawa, S Yazawa, O Nishimura… - Zoological science, 2014 - BioOne
Ground beetles of the subgenus Ohomopterus (genus Carabus) show marked divergence
in species-specific male and female genital morphologies, which contributes to reproductive …

Patient satisfaction with oral health check-ups at a community pharmacy and their effect on oral self-care habits and dental consultation behavior

H Iwata, K Shibano, M Okazaki, K Fujimaki… - Drug Discoveries & …, 2020 - jstage.jst.go.jp
Maintaining good oral health is important because oral diseases are related to systemic
diseases, and community pharmacies play a key role in maintaining the health of local residents…