Histone deacetylase inhibitors (HDACi) are currently being explored for the treatment of
both solid and hematological malignancies. Although originally thought to exert cytotoxic …

Parkinson’s disease (PD), a calamitous neurodegenerative disorder with no cure till date, is
closely allied with the misfolding and aggregation of α-Synuclein (α -Syn). Inhibition of α-Syn …

The SARS-CoV-2 contagion has had a huge impact on world population. It has been observed
that despite massive spread of the contagion in India particularly during the second wave…

Histone deacetylases have canonically been known to suppress gene expression via epigenetic
mechanism involving modulating histone acetylation status. While HDAC inhibitors are …

The conventional notions of pseudogenes being ‘junk DNA’ have largely been offset as
research studies have established their role in multiple biological processes. Our studies …

T cell Acute Lymphoblastic Leukemia (T-ALL) is a devastating malignancy found primarily in
pediatric populations. Although patient outcome has improved, standard of care for T-ALL …

Aged female microglia display a more inflammatory and disease-associated phenotype
compared to age-matched males. Epigenetic mechanisms, such as chromatin accessibility, are …

Background T cell Acute Lymphoblastic Leukemia (T-ALL) is a devastating malignancy
found primarily in pediatric populations. Standard of care for T-ALL has not progressed from …

Abstract Setting in of reproductive senescence (RS) gives rise to several changes, making
aged individuals susceptible to multiple disorders including neurodegenerative diseases, …

Setting in of reproductive senescence (RS) gives rise to several changes, making aged
individuals susceptible to neurodegenerative diseases, cardiovascular and bone disorders …