[PDF][PDF] Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

…, K Ejima, Y Koizumi, T Tanaka, S Aoki, K Kuramochi… - Iscience, 2021 - cell.com
Antiviral treatments targeting the coronavirus disease 2019 are urgently required. We
screened a panel of already approved drugs in a cell culture model of severe acute respiratory …

Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets

…, K Morohashi, A Yilmaz, K Kuramochi… - Proceedings of the …, 2013 - National Acad Sciences
Flavonoids constitute the largest class of dietary phytochemicals, adding essential health
value to our diet, and are emerging as key nutraceuticals. Cellular targets for dietary …

Multidrug treatment with nelfinavir and cepharanthine against COVID-19

…, K Ejima, Y Koizumi, T Tanaka, S Aoki, K Kuramochi… - BioRxiv, 2020 - biorxiv.org
Antiviral treatments targeting the emerging coronavirus disease 2019 (COVID-19) are
urgently required. We screened a panel of already-approved drugs in a cell culture model of …

Oligonaphthofurans: fan-shaped and three-dimensional π-compounds

…, T Tsuji, K Uenaka, K Kuramochi… - Journal of the …, 2014 - ACS Publications
Using a bottom-up method, we prepared a series of oligonaphthofurans composed of alternating
naphthalene rings and furan rings. The largest compound (compound 25) contained 8 …

[HTML][HTML] Identification of anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) oxysterol derivatives in vitro

…, M Kataoka, M Yamasaki, K Kuramochi… - International journal of …, 2021 - mdpi.com
The development of effective antiviral drugs targeting the severe acute respiratory syndrome-related
coronavirus 2 (SARS-CoV-2) is urgently needed to combat the coronavirus disease …

[HTML][HTML] Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro

…, W Saso, T Tanaka, S Aoki, K Kuramochi… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) has caused serious public health, social, and
economic damage worldwide and effective drugs that prevent or cure COVID-19 are urgently …

[HTML][HTML] Suppression of allergic and inflammatory responses by essential oils derived from herbal plants and citrus fruits

…, T Jippo, K Kuramochi… - International …, 2014 - spandidos-publications.com
The aim of the present study was to investigate the biological activity of 20 essential oils (EOs)
derived from herbal plants and citrus fruits. The in vitro anti-allergic and anti-inflammatory …

Exhaustive syntheses of naphthofluoresceins and their functions

E Azuma, N Nakamura, K Kuramochi… - The Journal of …, 2012 - ACS Publications
Naphthofluorescein and/or seminaphthofluorescein derivatives possessing the additional
benzene units to one or both sides of fluorescein were exhaustively constructed through …

1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae

M Naganuma, M Nishida, K Kuramochi… - Bioorganic & medicinal …, 2008 - Elsevier
Talaroflavone (1) and 1-deoxyrubralactone (2) are natural compounds isolated from
cultures of a fungal strain derived from sea algae, and their structures were determined by …

Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation

Y Myobatake, T Takeuchi, K Kuramochi… - Journal of natural …, 2012 - ACS Publications
Pinophilins A (1) and B (2), new hydrogenated azaphilones, and Sch 725680 (3) were isolated
from cultures of a fungus (Penicillium pinophilum Hedgcok) derived from a seaweed, and …