In mammalian male meiosis, the heterologous X and Y chromosomes remain unsynapsed
and, as a result, are subject to meiotic sex chromosome inactivation (MSCI). MSCI is required …

Gametogenesis is dependent on the expression of germline-specific genes. However, it
remains unknown how the germline epigenome is distinctly established from that of somatic …

During spermatogenesis, germ cells undergo massive cellular reconstruction and dynamic
chromatin remodeling to facilitate highly diverse transcriptomes, which are required for the …

Germ cells manifest a unique gene expression program and regain totipotency in the zygote.
Here, we perform Hi-C analysis to examine 3D chromatin organization in male germ cells …

Gene regulation in the germline ensures the production of high-quality gametes, long-term
maintenance of the species and speciation. Male germline transcriptomes undergo dynamic …

During meiosis, DNA damage response (DDR) proteins induce transcriptional silencing of
unsynapsed chromatin, including the constitutively unsynapsed XY chromosomes in males. …

Owing to bursts in the expression of thousands of germline-specific genes, the testis has the
most diverse and complex transcriptome of all organs. By analyzing the male germline of …

Repressive H3K27me3 and active H3K4me2/3 together form bivalent chromatin domains,
molecular hallmarks of developmental potential. In the male germline, these domains are …

Fanconi anemia (FA) is a recessive X-linked and autosomal genetic disease associated
with bone marrow failure and increased cancer, as well as severe germline defects such as …

During spermatogenesis, a large number of germline genes essential for male fertility are
coordinately activated. However, it remains unknown how timely activation of this group of …