[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

…, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

[HTML][HTML] Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

…, KY Sit, L Martinez-Sobrido, WC Liu, KM White… - Nature, 2020 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

…, M Gupta, S Pourmal, EW Titus, M Cakir, M Soucheray… - Science, 2020 - science.org
INTRODUCTION The emergence of three lethal coronaviruses in <20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, …

[PDF][PDF] The global phosphorylation landscape of SARS-CoV-2 infection

M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds …

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

…, K Leon, KM White, US Chio, M Gupta, M Jin… - Science, 2020 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters host cells
via an interaction between its Spike protein and the host cell receptor angiotensin-converting …

[HTML][HTML] Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

…, LW Updyke, S Weston, Y Zhu, KM White… - Nature …, 2021 - nature.com
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease
is a virally encoded protein that is essential across a broad spectrum of coronaviruses with …

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

KM White, R Rosales, S Yildiz, T Kehrer, L Miorin… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins interact with
the eukaryotic translation machinery, and inhibitors of translation have potent antiviral effects. …

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

…, E Moreno, O Danziger, KM White… - Proceedings of the …, 2020 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health …

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

…, A Fischer, MJ O'meara, B Monel, T Vallet, KM White… - Science, 2021 - science.org
Repurposing drugs as treatments for COVID-19, the disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning with …

[PDF][PDF] Transcription elongation can affect genome 3D structure

…, MW Chang, N Givarkes, A Rialdi, KM White… - Cell, 2018 - cell.com
How transcription affects genome 3D organization is not well understood. We found that during
influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell chromatin …