Most great ape genetic variation remains uncharacterized 1 , 2 ; however, its study is critical
for understanding population history 3 , 4 , 5 , 6 , recombination 7 , selection 8 and …

By impairing both function and survival, the severe reduction in oxygen availability associated
with high-altitude environments is likely to act as an agent of natural selection. We used …

Farming and sedentism first appeared in southwestern Asia during the early Holocene and
later spread to neighboring regions, including Europe, along multiple dispersal routes. …

Individuals with severe, sporadic disorders of infantile onset represent an important class of
disease for which discovery of the underlying genetic architecture is not amenable to …

It is commonly thought that human genetic diversity in non-African populations was shaped
primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a …

Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal
rearrangement and occupy a key node in the primate phylogeny between Old World …

Purpose The management of epilepsy in children is particularly challenging when seizures
are resistant to antiepileptic medications, or undergo many changes in seizure type over time…

We sequenced Early Neolithic genomes from the Zagros region of Iran (eastern Fertile
Crescent), where some of the earliest evidence for farming is found, and identify a previously …

Europe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic
remains and having been the centre of modern dog breed creation. Here we sequence …

We report the discovery of an African American Y chromosome that carries the ancestral
state of all SNPs that defined the basal portion of the Y chromosome phylogenetic tree. We …