We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …

Gene targeting studies in primary human islets could advance our understanding of mechanisms
driving diabetes pathogenesis. Here, we demonstrate successful genome editing in …

Delineating gene regulatory networks that orchestrate cell-type specification is a continuing
challenge for developmental biologists. Single-cell analyses offer opportunities to address …

The notochord is a defining feature of all chordates. The transcription factors Zic and ETS
regulate enhancer activity within the notochord. We conduct high-throughput screens of …

Reliance on rodents for understanding pancreatic genetics, development and islet function
could limit progress in developing interventions for human diseases such as diabetes mellitus…

Little is known about regulated glucagon secretion by human islet α-cells compared to
insulin secretion from β-cells, despite conclusive evidence of dysfunction in both cell types in …

<p>Mutations in the gene encoding the transcription factor regulatory factor X-box binding 6
(RFX6) are associated with human diabetes. Within pancreatic islets, <italic>RFX6</italic> …

The islets of Langerhans are endocrine organs characteristically dispersed throughout the
pancreas. During development, endocrine progenitors delaminate, migrate radially and …

We have created a compendium of single cell transcriptome data from the model organism
Mus musculus comprising nearly 100,000 cells from 20 organs and tissues. These data …

Glucose homeostasis is a common process throughout the animal kingdom. The importance
of glucose control is made apparent by the mortality of diseases that affect energy …