Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

The anatomical and functional architecture of the human brain is mainly determined by prenatal
transcriptional processes. We describe an anatomically comprehensive atlas of the mid-…

The neocortex is disproportionately expanded in human compared with mouse 1 , 2 , both
in its total volume relative to subcortical structures and in the proportion occupied by …

Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor’s
molecular and cellular landscapes are complex, and their relationships to histologic features …

We present a unique, extensive, and open synaptic physiology analysis platform and dataset.
Through its application, we reveal principles that relate cell type to synaptic properties and …

Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To …

The transcriptional underpinnings of brain development remain poorly understood,
particularly in humans and closely related non-human primates. We describe a high-resolution …

10.7554/eLife.31126.001 As more people live longer, age-related neurodegenerative
diseases are an increasingly important societal health issue. Treatments targeting specific …

Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric
acid–producing (GABAergic) neurons from subclasses to a high diversity of more …