The ability to noninvasively measure endogenous pancreatic β-cell mass (BCM) would
accelerate research on the pathophysiology of diabetes and revolutionize the preclinical …

The discovery of ketamine as a rapid and robust antidepressant marks the beginning of a
new era in the treatment of psychiatric disorders. Ketamine is thought to produce rapid and …

Although [ 11 C]‐(+)‐PHNO has enabled quantification of the dopamine‐D3 receptor (D3R)
in the human brain in vivo, its selectivity for the D3R is not sufficiently high to allow us to …

Background The 18-kDa translocator protein (TSPO) is an important target for assessing
neuroimmune function in brain with positron-emission tomography (PET) imaging. The goal of …

Purpose To quantify the synaptic vesicle glycoprotein 2A (SV2A) changes in the whole
central nervous system (CNS) under pathophysiological conditions, a high affinity SV2A PET …

[ 11 C]MRB is one of the most promising radioligands used to measure brain norepinephrine
transporters (NET) with positron emission tomography (PET). The objective of this study …

Motor symptoms in Parkinson disease (PD) are caused by a loss of dopamine input from the
substantia nigra to the striatum. Blockade of adenosine 2A (A 2A ) receptors facilitates …

Background Compulsive patterns of drug use are thought to be the consequence of drug-induced
adaptations in the neural mechanisms that enable behavior to be flexible. …

Purpose Exploring synaptic density changes during brain growth is crucial to understanding
brain development. Previous studies in nonhuman primates report a rapid increase in …

Purpose Currently, there are multiple active clinical trials involving poly(ADP-ribose)
polymerase (PARP) inhibitors in the treatment of glioblastoma. The noninvasive quantification of …