Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4)
that are spreading into new territories is an important goal of vaccine design. To …

Serology has provided valuable diagnostic and epidemiological data on antibody responses
to SARS-CoV-2 in diverse patient cohorts. Deployment of high content, multiplex serology …

Phenotypic screening of antigen-specific antibodies in human blood is a common diagnostic
test for infectious agents and a correlate of protection after vaccination. In addition to long-…

Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic
cell transplantation and is largely mediated by activated donor lymphocytes. Lymphotoxin (LT…

A multiplexed enzyme-linked immunosorbent assay (ELISA) that simultaneously measures
antibody binding to multiple antigens can extend the impact of serosurveillance studies, …

The sequencing of antibody repertoires of B-cells at increasing coverage and depth has led
to the identification of vast numbers of immunoglobulin heavy and light chains. However, the …

We describe an adaptation of conventional ELISA methods to an ELISA-Array format using
non-contact Piezo printing of up to 30 spots of purified recombinant viral fusion proteins and …

Viral entry targets with therapeutic neutralizing potential are subject to multiple escape
mechanisms, including antigenic drift, immune dominance of functionally irrelevant epitopes, and …

We developed a neutralizing antibody assay (NAb assay), based upon the complement-dependent
cytotoxicity (CDC) activity of a monoclonal human IgG 1 therapeutic (IgT), to …

Pharmacokinetic (PK) and immunohistochemistry (IHC) assays are essential to the
evaluation of the safety and efficacy of therapeutic monoclonal antibodies (mAb) during drug …