The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations in …

We assessed the geographical distribution of C9orf72 G 4 C 2 expansions in a pan‐ E
uropean frontotemporal lobar degeneration ( FTLD ) cohort (n = 1,205), ascertained by the E …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in families
with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD came …

We assessed the impact of amyloid precursor protein (APP) gene locus duplications in early
onset Alzheimer's disease in a Dutch population-based sample. Using real-time PCR and …

With the advent of genome-wide association studies (GWAS) and next-generation sequencing,
more than 20 risk loci that affect Alzheimer's disease have been identified. These loci are …

Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved disease …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a …