Serial electron microscopy and 3-D reconstructions of dendritic spines from hippocampal area
CA 1 dendrites were obtained to evaluate 2 questions about relationships between spine …

Dendritic spines are distinguished by their shapes, subcellular composition, and synaptic
receptor subtypes. Recent studies show that actin-dependent movements take place in spine …

Consolidation of implicit memory in the invertebrate Aplysia and explicit memory in the
mammalian hippocampus are associated with remodeling and growth of preexisting synapses …

It has long been hypothesized that changes in dendritic spine structure may modify the
physiological properties of synapses located on them. Due to their small size, large number, and …

Dendritic spines, the tiny protrusions that stud the surface of many neurons, are the location
of over 90% of all excitatory synapses that occur in the eNS. Their small size has, in large …

Neurotrophins regulate neuronal survival, differentiation, and synaptic function. To understand
how neurotrophins elicit such diverse responses, we elucidated signaling pathways by …

Altered dendritic spines are characteristic of traumatized or diseased brain. Two general
categories of spine pathology can be distinguished: pathologies of distribution and pathologies …

Dendritic spines are micron-sized membrane protrusions receiving most excitatory synaptic
inputs in the mammalian brain. Spines form and grow during long-term potentiation (LTP) of …

Physiological studies of CA3→CA1 synaptic transmission and plasticity have revealed both
pre- and postsynaptic effects. Understanding the extent to which individual presynaptic …

The morphology and molecular composition of synapses provide the structural basis for
synaptic function. This article reviews the electron microscopy of excitatory synapses on …