It has long been hypothesized that changes in dendritic spine structure may modify the
physiological properties of synapses located on them. Due to their small size, large number, and …

Serial electron microscopy and 3-D reconstructions of dendritic spines from hippocampal area
CA 1 dendrites were obtained to evaluate 2 questions about relationships between spine …

Dendritic spines, the tiny protrusions that stud the surface of many neurons, are the location
of over 90% of all excitatory synapses that occur in the eNS. Their small size has, in large …

Neurotrophins regulate neuronal survival, differentiation, and synaptic function. To understand
how neurotrophins elicit such diverse responses, we elucidated signaling pathways by …

Dendritic spines are the primary recipients of excitatory input in the central nervous system.
They provide biochemical compartments that locally control the signaling mechanisms at …

Recent studies show that glutamate transporter-mediated currents occur in astrocytes when
glutamate is released from hippocampal synapses. These transporters remove excess …

To determine the role of dendritic filopodia in the genesis of excitatory synaptic contacts and
dendritic spines in hippocampal area CA1, serial section electron microscopy and three-…

Altered dendritic spines are characteristic of traumatized or diseased brain. Two general
categories of spine pathology can be distinguished: pathologies of distribution and pathologies …

Dendritic spines are the primary site of excitatory input on most principal neurons. Long-lasting
changes in synaptic activity are accompanied by alterations in spine shape, size and …

Recent studies have shown high levels of calcium in activated dendritic spines, where the
smooth endoplasmic reticulum (SER) is likely to be important for regulating calcium. Here, the …