Extracellular β-amyloid (Aβ) plaque deposits and inflammatory immune activation are thought
to alter various aspects of tissue microstructure, such as extracellular free water, fractional …

Understanding the biological functions of tau variants can illuminate differential etiologies of
Alzheimer’s disease (AD) and primary tauopathies. Though the end-stage …

Background The S209F variant of Abelson Interactor Protein 3 (ABI3) increases risk for
Alzheimer’s disease (AD), but little is known about its function in relation to AD pathogenesis. …

Aims To illuminate the pathological synergy between Aβ and tau leading to emergence of
neurofibrillary tangles (NFT) in Alzheimer's disease (AD), here, we have performed a …

Purpose Low-dose naltrexone (LDN) has increased in popularity as a non-opioid
medication that may decrease chronic pain symptoms. LDN is most commonly used to treat …

Inflammatory signaling is thought to modulate the neurodegenerative cascade in amyotrophic
lateral sclerosis (ALS). We have previously shown that expression of Interleukin-10 (IL-10)…

Introduction Management of urachal anomalies in pediatric patients has historically lacked a
clear consensus between conservative and surgical management. We aimed to review and …

Introduction: Holmium laser lithotripsy is a standard energy source used for treatment of kidney
stones during flexible ureteroscopy. Efficiency of laser surgery may be affected by patient …

Introduction Persistence of embryonic urachal structures due to a failure of the urachus to
involute into the median umbilical ligament is known as a urachal anomaly (UA). UAs may …

Background Alzheimer’s disease (AD) is a neurodegenerative disease characterized
pathologically by intracellular neurofibrillary tangles (NFT), extracellular amyloid β (Aβ) plaques, …