Export of proteins from the endoplasmic reticulum in COPII-coated vesicles occurs at
defined sites that contain the scaffolding protein Sec16. We identify TFG-1, a new conserved …

The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent
aneuploidy and chromosomal instability, which are hallmarks of tumor cells. Reduced …

10.7554/eLife.26722.001 Cell polarization underlies many cellular and organismal functions.
The GTPase Cdc42 orchestrates polarization in many contexts. In budding yeast, …

Robust cell–cell adhesion is critical for tissue integrity and morphogenesis, yet little is known
about the molecular mechanisms controlling cell–cell junction architecture and strength. …

Phospholipase A 2 activity plays key roles in generating lipid second messengers and
regulates membrane topology through the generation of asymmetric lysophospholipids. In …

Cell polarization underlies many cellular and organismal functions. The GTPase Cdc42
orchestrates polarization in many contexts. In budding yeast, polarization is associated with a …

The wind whips across the beach, bringing a surprising chill to an otherwise sunny day–though
spring in Chicago is anything but predictable. As the cold seeps into your gloveless …

The aim of this study was to uncover factors accounting for the ability of children with
specific language impairment (SLI) to learn agreement morphemes in intervention. Twenty-five …

This work could not have been undertaken without the encouragement and support of
Soprintendente, Prof. Pier Giovanni Guzzo, Direttore, dott. Antonio D’Ambrosio, and the entire staff …

Lower-limb exoskeletons capable of comfortably applying high torques at high bandwidth can
be used to probe the human neuromuscular system and assist gait. We designed and built …