The pancreas originates from two epithelial evaginations of the foregut, which consist of
multipotent epithelial progenitors that organize into a complex tubular epithelial network. The …

Notch signaling controls proliferation of multipotent pancreatic progenitor cells (MPCs) and
their segregation into bipotent progenitors (BPs) and unipotent pro-acinar cells (PACs). Here, …

Objective Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic
islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In …

PRDM family members are transcriptional regulators involved in tissue specific differentiation.
PRDM5 has been reported to predominantly repress transcription, but a characterization …

PRDM proteins belong to the SET domain protein family, which is involved in the regulation
of gene expression. Although few PRDM members possess histone methyltransferase …

Notch signalling and the downstream effector HES1 is required for multiple pancreatic cell
fate choices during development, but the direct target genes remain poorly characterised. …

Natural Killer (NK) cells represent the cytotoxic member within the innate lymphoid cell (ILC)
family that are important against viral infections and cancer. While the NK cell emergence …

Genetic differences between pluripotent stem cell lines causes variable activity of extra-cellular
signaling pathways, which limits the reproducibility of directed differentiation protocols. …

Objective: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic
islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In …

Natural Killer (NK) cell development has not been completely elucidated, in part due to the
lack of a suitable in vitro model that recapitulates NK cell emergence during human …