Histones are frequently decorated with covalent modifications. These histone modifications
are thought to be involved in various chromatin-dependent processes including transcription. …

Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not
distributed uniformly along the human genome. Instead, different human genomic regions vary …

Biological insights can be obtained through computational integration of genomics data sets
consisting of diverse types of information. The integration is often hampered by a large …

Background PSAIA (Protein Structure and Interaction Analyzer) was developed to compute
geometric parameters for large sets of protein structures in order to predict and investigate …

Identifying interaction sites in proteins provides important clues to the function of a protein
and is becoming increasingly relevant in topics such as systems biology and drug discovery. …

Background There are a number of methods (also called: measures) currently in use that
quantify codon usage in genes. These measures are often influenced by other sequence …

The WWW servers at http://www.icgeb.trieste.it/dna/ are dedicated to the analysis of user-submitted
DNA sequences; plot.it creates parametric plots of 45 physicochemical, as well as …

In mammals, a single Dicer participates in biogenesis of small RNAs in microRNA (miRNA)
and RNAi pathways. In mice, endogenous RNAi is highly active in oocytes, but not in somatic …

Codon usage bias in prokaryotic genomes is largely a consequence of background substitution
patterns in DNA, but highly expressed genes may show a preference towards codons …

Nonintegrative AAV-mediated gene therapy in the liver is effective in adult patients but faces
limitations in pediatric settings because of episomal DNA loss during hepatocyte …