COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms

…, JE Shoemaker, J Zucker, K Oxford… - Molecular systems …, 2021 - embopress.org
We need to effectively combine the knowledge from surging literature with complex datasets
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …

[HTML][HTML] Protein coding content of the ULb′ region of wild-type rhesus cytomegalovirus

KL Oxford, MK Eberhardt, KW Yang, L Strelow, S Kelly… - Virology, 2008 - Elsevier
A recent comparison of two rhesus cytomegalovirus (RhCMV) genomes revealed that the
region at the right end of the U L genome component (U L b′) undergoes genetic alterations …

Open reading frames carried on UL/b′ are implicated in shedding and horizontal transmission of rhesus cytomegalovirus in rhesus monkeys

KL Oxford, L Strelow, Y Yue, WLW Chang… - Journal of …, 2011 - Am Soc Microbiol
Implicit with the use of animal models to test human cytomegalovirus (HCMV) vaccines is
the assumption that the viral challenge of vaccinated animals reflects the anticipated virus-host …

Vaccine-induced control of viral shedding following rhesus cytomegalovirus challenge in rhesus macaques

…, A Dasgupta, Z Li, KA Schmidt, KL Oxford… - Journal of …, 2011 - Am Soc Microbiol
The use of animal models of human cytomegalovirus (HCMV) infection is critical to refine
HCMV vaccine candidates. Previous reports have demonstrated that immunization of rhesus …

[HTML][HTML] The interplay between immune maturation, age, chronic viral infection and environment

KL Oxford, MGA dela Pena-Ponce, K Jensen… - Immunity & …, 2015 - Springer
Background The worldwide increase in life expectancy has been associated with an increase
in age-related morbidities. The underlying mechanisms resulting in immunosenescence …

Leveraging structured biological knowledge for counterfactual inference: a case study of viral pathogenesis

…, C Bakker, J Teuton, CT Hoyt, K Oxford… - … Transactions on Big …, 2021 - ieeexplore.ieee.org
Counterfactual inference is a useful tool for comparing outcomes of interventions on
complex systems. It requires us to represent the system in form of a structural causal model, …

[HTML][HTML] Human herpes simplex virus type 1 in confiscated gorilla

KVK Gilardi, KL Oxford, D Gardner-Roberts… - Emerging infectious …, 2014 - ncbi.nlm.nih.gov
In 2007, we detected human herpes simplex virus type 1, which caused stomatitis, in a
juvenile confiscated eastern lowland gorilla (Gorilla beringei graueri) that had a high degree of …

Immunogenicity of a vaccine formulated with the Chlamydia trachomatis serovar F, native major outer membrane protein in a nonhuman primate model

C Cheng, S Pal, I Bettahi, KL Oxford, PA Barry… - Vaccine, 2011 - Elsevier
To determine the ability of a vaccine formulated with the genital Chlamydia trachomatis, serovar
F, native major outer membrane protein (Ct-F-nMOMP), to induce systemic and mucosal …

The landscape of viral proteomics and its potential to impact human health

KL Oxford, JP Wendler, JE McDermott… - Expert review of …, 2016 - Taylor & Francis
Introduction: Advances in mass spectrometry-based proteomic technologies are enhancing
studies of viral pathogenesis. Identification and quantification of host and viral proteins and …

Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV infection

…, SV Westmoreland, A Kaur, KL Oxford… - Journal of …, 2012 - Am Soc Microbiol
We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in
infected macaques was related to UL/b′ coding content. Acute biopsy specimens of the …