User profiles for Kristijan Ramadan
 | Kristijan RamadanOxford Professor of Molecular Medicine Verified email at oncology.ox.ac.uk Cited by 3938 |
[HTML][HTML] Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity
…, N Kaczmarek, K Bachmann, K Ramadan… - Nature …, 2014 - nature.com
DNA damage recognition subunits such as DDB2 and XPC protect the human skin from
ultraviolet (UV) light-induced genome instability and cancer, as demonstrated by the devastating …
ultraviolet (UV) light-induced genome instability and cancer, as demonstrated by the devastating …
[HTML][HTML] TEX264 coordinates p97-and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
…, TS Maughan, SF El-Khamisy, K Ramadan - Nature …, 2020 - nature.com
Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA
replication and transcription. TOP1 is also a major driver of endogenous genome instability, …
replication and transcription. TOP1 is also a major driver of endogenous genome instability, …
Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features
Age-related degenerative and malignant diseases represent major challenges for health
care systems. Elucidation of the molecular mechanisms underlying carcinogenesis and age-…
care systems. Elucidation of the molecular mechanisms underlying carcinogenesis and age-…
A unified model for the G1/S cell cycle transition
Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage and …
However, hyperactive or expedited S phase entry causes replication stress, DNA damage and …
[HTML][HTML] Role of p97/VCP (Cdc48) in genome stability
Ubiquitin-dependent molecular chaperone p97, also known as valosin-containing protein (VCP)
or Cdc48, is an AAA ATPase involved in protein turnover and degradation. p97 converts …
or Cdc48, is an AAA ATPase involved in protein turnover and degradation. p97 converts …
[HTML][HTML] DNA–protein crosslink proteases in genome stability
A Ruggiano, K Ramadan - Communications Biology, 2021 - nature.com
Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
K Ramadan, R Bruderer, FM Spiga, O Popp, T Baur… - Nature, 2007 - nature.com
During division of metazoan cells, the nucleus disassembles to allow chromosome segregation,
and then reforms in each daughter cell. Reformation of the nucleus involves chromatin …
and then reforms in each daughter cell. Reformation of the nucleus involves chromatin …
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant
transformation or cell death 1 . Cells respond to DSBs with the ordered recruitment of …
transformation or cell death 1 . Cells respond to DSBs with the ordered recruitment of …
[PDF][PDF] Metalloprotease SPRTN/DVC1 orchestrates replication-coupled DNA-protein crosslink repair
The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block
the progression of DNA replication. DPCs frequently occur in cells, either as a consequence …
the progression of DNA replication. DPCs frequently occur in cells, either as a consequence …
[PDF][PDF] Targeting BRCA1 and BRCA2 deficiencies with G-quadruplex-interacting compounds
G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural
replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous …
replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous …