T cell immunity can potentially eradicate malignant cells and lead to clinical remission in a
minority of patients with cancer. In the majority of these individuals, however, there is a failure …

Active immunization using tumor antigen-loaded dendritic cells holds promise for the adjuvant
treatment of cancer to eradicate or control residual disease, but so far, most dendritic cell …

The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell
receptor (TCR) genes is critical for our understanding of the adaptive immune system and …

T cell memory relies on the generation of antigen-specific progenitors with stem-like
properties. However, the identity of these progenitors has remained unclear, precluding a full …

In 2016, we started a community effort to gather and curate publicly available sequence
data acquired from T cell receptor (TCRs) with defined antigen specificities, as well as …

γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without
clonal selection and differentiation. Here we use next-generation sequencing to probe how …

Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR)
that detects microbial metabolites presented by the nonpolymorphic major histocompatibility …

Relapse is a major problem in acute myeloid leukemia (AML) and adversely affects survival.
In this phase 2 study, we investigated the effect of vaccination with dendritic cells (DCs) …

The human leukocyte antigen–A2 (HLA-A2)–restricted zinc transporter 8 186–194 (ZnT8
186–194 ) and other islet epitopes elicit interferon-γ secretion by CD8 + T cells preferentially in …

Purpose: Epstein–Barr virus (EBV) is associated with several cancers in which the tumor cells
express EBV antigens EBNA1 and LMP2. A therapeutic vaccine comprising a recombinant …