Key points Synaptic excitation and inhibition must be properly balanced in individual neurons
and neuronal networks to allow proper brain function. Disrupting this balance may lead to …

Background Keratoconus (KC) is the most common ectatic corneal disease, characterized
by significantly localized thinning of the corneal stroma. Genetic, environmental, hormonal, …

A critical barrier in the treatment of endosomal and lysosomal diseases is the lack of
understanding of the in vivo functions of the putative causative genes. We addressed this by …

Ureteropelvic junction obstruction (UPJO) is the most common cause of urinary tract obstruction
in pediatric patients. Debates in management include ureteral stent versus nephrostomy …

Background Keratoconus (KC) is the most common ectatic corneal disease, characterized
by significantly localized thinning of the corneal stroma. Genetic, environmental, hormonal, …

disease syndrome and porcine circovirus–associated disease, and can establish a lifelong
subclinical infection6. In 2006, a more severe form of the disease, called highly pathogenic …

The major histocompatibility complex (MHC) is an extraordinarily diverse cluster of genes that
play a key role in the immune system. MHC gene products are also found in various body …

… Most importantly, I thank my parents, Steve and Lori Ates, for always being there for me with
a listening ear, even though they were hundreds of miles away. They served as a steadfast …

A large body of evidence suggests that major histocompatibility complex (MHC) genotype
influences mate choice. However, few studies have investigated MHC‐mediated post‐…

To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide
association study of 16 million SNPs identified through whole-genome sequencing of …