[HTML][HTML] A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides

…, J Blank, KM Holton, T Ahfeldt, M Furlong… - Nature …, 2023 - nature.com
Parkinson’s disease (PD) is a complex neurodegenerative disease with etiology rooted in
genetic vulnerability and environmental factors. Here we combine quantitative epidemiologic …

Longitudinal trajectory of early functional recovery in patients with first episode psychosis

MH Hall, KM Holton, D Öngür, D Montrose… - Schizophrenia …, 2019 - Elsevier
Background There is a large variability in the recovery trajectory and outcome of first episode
of psychosis [FEP] patients. To date, individuals' outcome trajectories at early stage of …

[PDF][PDF] Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming

…, SA Boswell, N Ron-Harel, AE Ringel, KM Holton… - Cell systems, 2019 - cell.com
Tyrosine kinase inhibitors (TKIs) are widely used to treat solid tumors but can be cardiotoxic.
The molecular basis for this toxicity and its relationship to therapeutic mechanisms remain …

High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly

…, SG Susco, D Lam, A Messana, KM Holton… - Elife, 2023 - elifesciences.org
Resolving fundamental molecular and functional processes underlying human synaptic
development is crucial for understanding normal brain function as well as dysfunction in disease…

[HTML][HTML] Creb5 establishes the competence for Prg4 expression in articular cartilage

…, Y Gao, U Jadhav, HH Hung, KM Holton… - Communications …, 2021 - nature.com
A hallmark of cells comprising the superficial zone of articular cartilage is their expression of
lubricin, encoded by the Prg4 gene, that lubricates the joint and protects against the …

[HTML][HTML] Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

M Ximerakis, KM Holton, RM Giadone, C Ozek… - Nature Aging, 2023 - nature.com
Aging is a complex process involving transcriptomic changes associated with deterioration
across multiple tissues and organs, including the brain. Recent studies using heterochronic …

[HTML][HTML] Exploring the influence of functional architecture on cortical thickness networks in early psychosis–A longitudinal study

KM Holton, SY Chan, AJ Brockmeier, D Öngür, MH Hall - NeuroImage, 2023 - Elsevier
… Author links open overlay panel Kristina M. Holton a 1 , Shi Yu Chan b d 1 2 , Austin J.
Brockmeier a , Dost Öngür c d , Mei-Hua Hall b c d … Arain, M. Haque, L. Johal, P. …

[HTML][HTML] Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress

…, BJ Lang, A Murshid, TJ Borges, KM Holton… - Cell Stress and …, 2022 - Elsevier
Delivery of exogenous heat shock protein 90α (Hsp90α) and/or its induced expression in
neural tissues has been suggested as a potential strategy to combat neurodegenerative …

[HTML][HTML] Cell types differ in global coordination of splicing and proportion of highly expressed genes

EF Trakhtenberg, N Pho, KM Holton, TW Chittenden… - Scientific reports, 2016 - nature.com
Balance in the transcriptome is regulated by coordinated synthesis and degradation of RNA
molecules. Here we investigated whether mammalian cell types intrinsically differ in global …

[HTML][HTML] Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets

…, RM Giadone, A Ordureau, KM Holton… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron (MN) disease with severely
limited treatment options. Identification of effective treatments has been limited in part by …