[HTML][HTML] A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides
Parkinson’s disease (PD) is a complex neurodegenerative disease with etiology rooted in
genetic vulnerability and environmental factors. Here we combine quantitative epidemiologic …
genetic vulnerability and environmental factors. Here we combine quantitative epidemiologic …
Longitudinal trajectory of early functional recovery in patients with first episode psychosis
MH Hall, KM Holton, D Öngür, D Montrose… - Schizophrenia …, 2019 - Elsevier
Background There is a large variability in the recovery trajectory and outcome of first episode
of psychosis [FEP] patients. To date, individuals' outcome trajectories at early stage of …
of psychosis [FEP] patients. To date, individuals' outcome trajectories at early stage of …
[PDF][PDF] Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming
…, SA Boswell, N Ron-Harel, AE Ringel, KM Holton… - Cell systems, 2019 - cell.com
Tyrosine kinase inhibitors (TKIs) are widely used to treat solid tumors but can be cardiotoxic.
The molecular basis for this toxicity and its relationship to therapeutic mechanisms remain …
The molecular basis for this toxicity and its relationship to therapeutic mechanisms remain …
High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly
…, SG Susco, D Lam, A Messana, KM Holton… - Elife, 2023 - elifesciences.org
Resolving fundamental molecular and functional processes underlying human synaptic
development is crucial for understanding normal brain function as well as dysfunction in disease…
development is crucial for understanding normal brain function as well as dysfunction in disease…
[HTML][HTML] Creb5 establishes the competence for Prg4 expression in articular cartilage
…, Y Gao, U Jadhav, HH Hung, KM Holton… - Communications …, 2021 - nature.com
A hallmark of cells comprising the superficial zone of articular cartilage is their expression of
lubricin, encoded by the Prg4 gene, that lubricates the joint and protects against the …
lubricin, encoded by the Prg4 gene, that lubricates the joint and protects against the …
[HTML][HTML] Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
M Ximerakis, KM Holton, RM Giadone, C Ozek… - Nature Aging, 2023 - nature.com
Aging is a complex process involving transcriptomic changes associated with deterioration
across multiple tissues and organs, including the brain. Recent studies using heterochronic …
across multiple tissues and organs, including the brain. Recent studies using heterochronic …
[HTML][HTML] Exploring the influence of functional architecture on cortical thickness networks in early psychosis–A longitudinal study
… Author links open overlay panel Kristina M. Holton a 1 , Shi Yu Chan b d 1 2 , Austin J.
Brockmeier a , Dost Öngür c d , Mei-Hua Hall b c d … Arain, M. Haque, L. Johal, P. …
Brockmeier a , Dost Öngür c d , Mei-Hua Hall b c d … Arain, M. Haque, L. Johal, P. …
[HTML][HTML] Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress
Delivery of exogenous heat shock protein 90α (Hsp90α) and/or its induced expression in
neural tissues has been suggested as a potential strategy to combat neurodegenerative …
neural tissues has been suggested as a potential strategy to combat neurodegenerative …
[HTML][HTML] Cell types differ in global coordination of splicing and proportion of highly expressed genes
EF Trakhtenberg, N Pho, KM Holton, TW Chittenden… - Scientific reports, 2016 - nature.com
Balance in the transcriptome is regulated by coordinated synthesis and degradation of RNA
molecules. Here we investigated whether mammalian cell types intrinsically differ in global …
molecules. Here we investigated whether mammalian cell types intrinsically differ in global …
[HTML][HTML] Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets
…, RM Giadone, A Ordureau, KM Holton… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron (MN) disease with severely
limited treatment options. Identification of effective treatments has been limited in part by …
limited treatment options. Identification of effective treatments has been limited in part by …