User profiles for Kristof A. Torkenczy
Kristof A TorkenczyPost Doctoral Researcher at New York Genome center Verified email at nygenome.org Cited by 812 |
Sequencing thousands of single-cell genomes with combinatorial indexing
Single-cell genome sequencing has proven valuable for the detection of somatic variation,
particularly in the context of tumor evolution. Current technologies suffer from high library …
particularly in the context of tumor evolution. Current technologies suffer from high library …
Highly scalable generation of DNA methylation profiles in single cells
…, D Pokholok, SJ Norberg, KA Torkenczy… - Nature …, 2018 - nature.com
We present a highly scalable assay for whole-genome methylation profiling of single cells.
We use our approach, single-cell combinatorial indexing for methylation analysis (sci-MET), …
We use our approach, single-cell combinatorial indexing for methylation analysis (sci-MET), …
Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion
…, SS Fei, N Redmayne, KA Torkenczy… - Genome …, 2019 - genome.cshlp.org
Aneuploidy that arises during meiosis and/or mitosis is a major contributor to early embryo
loss. We previously showed that human preimplantation embryos encapsulate missegregated …
loss. We previously showed that human preimplantation embryos encapsulate missegregated …
The accessible chromatin landscape of the murine hippocampus at single-cell resolution
JR Sinnamon, KA Torkenczy, MW Linhoff… - Genome …, 2019 - genome.cshlp.org
Here we present a comprehensive map of the accessible chromatin landscape of the
mouse hippocampus at single-cell resolution. Substantial advances of this work include the …
mouse hippocampus at single-cell resolution. Substantial advances of this work include the …
[HTML][HTML] Spatially mapped single-cell chromatin accessibility
High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in complex
tissues, however, spatial orientation is lost. Here, we present single-cell combinatorial …
tissues, however, spatial orientation is lost. Here, we present single-cell combinatorial …
Improved single-cell ATAC-seq reveals chromatin dynamics of in vitro corticogenesis
Abstract Development is a complex process that requires the precise modulation of
regulatory gene networks controlled through dynamic changes in the epigenome. Single-cell-omic …
regulatory gene networks controlled through dynamic changes in the epigenome. Single-cell-omic …
Scalable and efficient single-cell DNA methylation sequencing by combinatorial indexing
Here we present a novel method: single-cell combinatorial indexing for methylation analysis
(sci-MET), which is the first highly scalable assay for whole genome methylation profiling of …
(sci-MET), which is the first highly scalable assay for whole genome methylation profiling of …
Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals
The transcription factor MYC (also c-Myc) induces histone modification, chromatin remodeling,
and the release of paused RNA polymerase to broadly regulate transcription. MYC is …
and the release of paused RNA polymerase to broadly regulate transcription. MYC is …
Single-Cell Sequencing of Primate Preimplantation Embryos Reveals Chromosome Elimination Via Cellular Fragmentation and Blastomere Exclusion
…, NH Lazar, SS Fei, N Redmayne, KA Torkenczy… - bioRxiv, 2018 - biorxiv.org
Aneuploidy that arises during meiosis and/or mitosis is a major contributor to early embryo
loss. We previously demonstrated that human preimplantation embryos encapsulate mis-…
loss. We previously demonstrated that human preimplantation embryos encapsulate mis-…
Integrated single-cell analysis reveals treatment-induced epigenetic homogenization
K Torkenczy, E Langer, A Fields… - Available at SSRN …, 2020 - papers.ssrn.com
Triple negative breast cancers (TNBC) constitute one-sixth of invasive female breast cancer
cases and are the most likely to develop resistance to treatment via genetic and/or …
cases and are the most likely to develop resistance to treatment via genetic and/or …