Neural progenitor cells (NPCs) from human induced pluripotent stem cells (hiPSCs) are
frequently induced using 3D culture methodologies however, it is unknown whether spheroid-…

The major drug binding site of sodium channels is inaccessible from the extracellular side,
drug molecules can only access it either from the membrane phase, or from the intracellular …

Agriculturally important crop plants emit a multitude of volatile organic compounds (VOCs),
which are excellent indicators of their health status and their interactions with pathogens and …

We investigated the mode of action of PNU-120596, a type II positive allosteric modulator of
the rat α7 nicotinic acetylcholine receptor expressed by GH4C1 cells, using patch-clamp and …

The alpha7 nicotinic acetylcholine receptor (nAChR) has some peculiar kinetic properties.
From the literature of α7 nAChR-mediated currents we concluded that experimentally …

Background and purpose: Ivabradine is clinically administered to lower the heart rate, proposedly
by inhibiting hyperpolarization-activated cyclic nucleotide-gated cation channels in the …

Background and Purpose Sodium channel inhibitors can be used to treat hyperexcitability‐related
diseases, including epilepsies, pain syndromes, neuromuscular disorders and …

Standard high throughput screening projects using automated patch-clamp instruments
often fail to grasp essential details of the mechanism of action, such as binding/unbinding …

We have developed an automated patch-clamp protocol that allows high information content
screening of sodium channel inhibitor compounds. We have observed that individual …

Cognitive impairment often involves the decreased expression or hypofunction of alpha 7-type
nicotinic acetylcholine receptors (α7 nAChRs). Agonists or positive allosteric modulators (…