The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases …

There is an urgent need for antiviral agents that treat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ongoing
coronavirus disease 2019 (COVID-19) pandemic underscores the need for new treatments. …

Huntington’s disease (HD) is a fatal, dominantly inherited neurodegenerative disorder
caused by CAG trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Since the …

Technologies capable of programmable translation activation offer strategies to develop
therapeutics for diseases caused by insufficient gene expression. Here, we present “translation-…

Bioluminescence imaging with luciferase–luciferin pairs is widely used in biomedical
research. Several luciferases have been identified in nature, and many have been adapted for …

Enzymes are powerful catalysts for site-selective C–H bond functionalization. Identifying
suitable enzymes for this task and for biocatalysis in general remains challenging, however, due …

The rapid spread of COVID-19 underscores the need for new treatments. Here we report
that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 …

Cell–cell interactions underlie fundamental biological processes but remain difficult to
visualize over long times and large distances in tissues and live organisms. Bioluminescence …

Cyclopropenes have emerged as a new class of bioorthogonal chemical reporters. These
strained rings can be metabolically introduced into target biomolecules and covalently …