Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice
K Lacek, K Vercauteren, K Grzyb, M Naddeo… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Hepatitis C virus (HCV)-induced end-stage liver disease is currently
the major indication for liver transplantation in the Western world. After transplantation, the …
the major indication for liver transplantation in the Western world. After transplantation, the …
[HTML][HTML] Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation
K Lacek, RA Urbanowicz, F Troise… - Journal of Biological …, 2014 - ASBMB
The broadly neutralizing antibodies HIV 2F5 and 4E10, which bind to overlapping epitopes
in the membrane-proximal external region of the fusion protein gp41, have been proposed to …
in the membrane-proximal external region of the fusion protein gp41, have been proposed to …
[HTML][HTML] Orf virus (ORFV) ANK-1 protein mitochondrial localization is mediated by ankyrin repeat motifs
K Lacek, B Bauer, K Bieńkowska-Szewczyk, HJ Rziha - Virus genes, 2014 - Springer
Orf virus (ORFV) strain D1701-V, a Parapoxvirus belonging to the family Poxviridae, became
attractive as a novel virus vector system that we successfully used for the generation of …
attractive as a novel virus vector system that we successfully used for the generation of …
Cholesterol conjugation potentiates the antiviral activity of an HIV immunoadhesin
RA Urbanowicz, K Lacek, A Lahm… - Journal of Peptide …, 2015 - Wiley Online Library
Immunoadhesins are engineered proteins combining the constant domain (Fc) of an antibody
with a ligand‐binding (adhesion) domain. They have significant potential as therapeutic …
with a ligand‐binding (adhesion) domain. They have significant potential as therapeutic …
The bat influenza H17N10 can be neutralized by broadly-neutralizing monoclonal antibodies and its neuraminidase can facilitate viral egress
The diversity of subtypes within the Influenza A virus genus has recently expanded with the
identification of H17N10 and H18N11 from bats. In order to further study the tropism and …
identification of H17N10 and H18N11 from bats. In order to further study the tropism and …
A first-in-class bispecific antibody CPL976 with a dual PD-L1/AXL mechanism of action that promotes common biological antitumor effects in in vitro and in vivo …
D Popiel, D Kołakowski, A Bojko-Matuszek, K Lacek… - Cancer Research, 2024 - AACR
Background: Bispecific antibodies emerged as a leading drug class for cancer therapy and
are becoming increasingly interesting for the therapeutic applications. The Gas6/Axl …
are becoming increasingly interesting for the therapeutic applications. The Gas6/Axl …
Abstract B146: Design and preclinical evaluation of CPL976-MMAE-novel, potent AXL-PD-L1 bispecific antibody conjugated with MMAE in targeted anticancer …
D Popiel, K Lacek, A Jabłońska, A Sowińska… - Molecular Cancer …, 2023 - AACR
Background: Antibody-drug conjugates (ADCs) combine the specificity of antibodies with the
potency of highly cytotoxic agents, reducing the off-target effects and improve effectiveness …
potency of highly cytotoxic agents, reducing the off-target effects and improve effectiveness …
[HTML][HTML] Abstract B121: CPL976, an innovative bispecific antibody targeting AXL and PD-L1 axis as a potential new anticancer therapeutic
…, D Kołakowski, M Bojko, A Sowińska, F Mituła, K Lacek… - NaN, 2023 - citedrive.com
… Agnieszka Bojko-Matuszek, Damian Kołakowski, Magdalena Bojko, Aleksandra Sowińska,
Filip Mituła, Krzysztof Lacek, Delfina Popiel, Sebastian Kwiatkowski, Tomasz Kornatowski …
Filip Mituła, Krzysztof Lacek, Delfina Popiel, Sebastian Kwiatkowski, Tomasz Kornatowski …
Characterization of ankyrin-repeat proteins (ANK) encoded by Orf virus (ORFV)
K Lacek - repozytorium.bg.ug.edu.pl
Orf virus (ORFV) strain D1701-V, a parapoxvirus belonging to the family Poxviridae possesses
strong immune-modulating properties, enhancing long-term immunity against different …
strong immune-modulating properties, enhancing long-term immunity against different …
Tropism and neutralisation studies on bat influenza H17N10
…, S Ghanny, P Soteropoulos, A Pessi, K Lacek… - Access …, 2020 - kar.kent.ac.uk
The diversity of subtypes within Influenza A recently expanded with identification of H17N10
and H18N11 from bats. To study the tropism and zoonotic potential of these viruses, we …
and H18N11 from bats. To study the tropism and zoonotic potential of these viruses, we …