Background Accurate and robust pathological image analysis for colorectal cancer (CRC)
diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patients’ …

Abstract Machine-assisted pathological recognition has been focused on supervised
learning (SL) that suffers from a significant annotation bottleneck. We propose a semi-supervised …

Epidermal growth factor-like domain-containing protein 7 (EGFL7) is upregulated in human
epithelial tumors and so is a potential biomarker for malignancy. Indeed, previous studies …

Background Vitex negundo L (Verbenaceae) is an aromatic shrub that is abundant in Asian
countries. A series of compounds from Vitex negundo have been used in traditional Chinese …

The M2 isoform of pyruvate kinase (PKM2), as a key glycolytic enzyme, plays important roles
in tumorigenesis and chemotherapeutic drug resistance. However, the intricate mechanism …

Purpose: To determine the role of UCH-L1 in regulating ERα expression, and to evaluate
whether therapeutic targeting of UCH-L1 can enhance the efficacy of anti-estrogen therapy …

Molecular subtypes of breast cancer are important references to personalized clinical treatment.
For cost and labor savings, only one of the patient’s paraffin blocks is usually selected …

Autophagy can protect stressed cancer cell by degradation of damaged proteins and organelles.
However, the regulatory mechanisms behind this cellular process remain incompletely …

Stratifin plays an important role in cancer biology by interfering with intracellular signalling
pathways and cell-cycle checkpoints. Decreased expression of stratifin gene has been …

Transforming growth factor-β (TGF-β), a multifunctional cytokine, exerts contradictory roles
in different kinds of cells. A number of studies have revealed its involvement in the …